mitogen-activated protein kinase kinase kinase / JUN kinase kinase kinase activity / negative regulation of motor neuron apoptotic process / positive regulation of protein kinase activity / post-translational protein modification / JNK cascade / positive regulation of JUN kinase activity / protein serine/threonine kinase activator activity / peptidyl-serine phosphorylation / growth cone ...mitogen-activated protein kinase kinase kinase / JUN kinase kinase kinase activity / negative regulation of motor neuron apoptotic process / positive regulation of protein kinase activity / post-translational protein modification / JNK cascade / positive regulation of JUN kinase activity / protein serine/threonine kinase activator activity / peptidyl-serine phosphorylation / growth cone / protein autophosphorylation / positive regulation of ERK1 and ERK2 cascade / protein kinase activity / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / positive regulation of DNA-templated transcription / protein kinase binding / protein homodimerization activity / ATP binding / membrane / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能
Mitogen-activated protein kinase kinase kinase 12/13 / Mitogen-activated protein kinase kinase kinase 12 / : / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
構造決定の手法: 分子置換 / 解像度: 2.2→60.56 Å / Cor.coef. Fo:Fc: 0.959 / Cor.coef. Fo:Fc free: 0.91 / SU B: 8.287 / SU ML: 0.197 / 交差検証法: THROUGHOUT / ESU R: 0.289 / ESU R Free: 0.231 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.2517
751
5.2 %
RANDOM
Rwork
0.17941
-
-
-
obs
0.1832
13630
99.96 %
-
溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK