登録情報 | データベース: PDB / ID: 8img |
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タイトル | Human cGAS catalytic domain bound with C20 |
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要素 | Cyclic GMP-AMP synthase |
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キーワード | IMMUNE SYSTEM / cGAS / inhibitor / C20 |
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機能・相同性 | 機能・相同性情報
cyclic GMP-AMP synthase / 2',3'-cyclic GMP-AMP synthase activity / STING mediated induction of host immune responses / paracrine signaling / poly-ADP-D-ribose modification-dependent protein binding / regulation of immunoglobulin production / cGAS/STING signaling pathway / pattern recognition receptor signaling pathway / regulation of T cell activation / cytoplasmic pattern recognition receptor signaling pathway ...cyclic GMP-AMP synthase / 2',3'-cyclic GMP-AMP synthase activity / STING mediated induction of host immune responses / paracrine signaling / poly-ADP-D-ribose modification-dependent protein binding / regulation of immunoglobulin production / cGAS/STING signaling pathway / pattern recognition receptor signaling pathway / regulation of T cell activation / cytoplasmic pattern recognition receptor signaling pathway / negative regulation of cGAS/STING signaling pathway / cGMP-mediated signaling / cellular response to exogenous dsRNA / positive regulation of type I interferon production / negative regulation of double-strand break repair via homologous recombination / nucleosome binding / positive regulation of defense response to virus by host / phosphatidylinositol-4,5-bisphosphate binding / activation of innate immune response / cAMP-mediated signaling / molecular condensate scaffold activity / determination of adult lifespan / positive regulation of cellular senescence / site of double-strand break / double-stranded DNA binding / defense response to virus / nuclear body / DNA repair / innate immune response / DNA damage response / chromatin binding / GTP binding / protein homodimerization activity / DNA binding / nucleoplasm / ATP binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Mab-21-like, nucleotidyltransferase domain / Mab-21-like, HhH/H2TH-like domain / Mab-21 protein HhH/H2TH-like domain / Mab-21 protein nucleotidyltransferase domain / Mab-21-like / Mab-21類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.8 Å |
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データ登録者 | Zhao, W.F. / Li, J.M. / Xu, Y.C. |
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資金援助 | 1件 |
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引用 | ジャーナル: Bioorg.Chem. / 年: 2023 タイトル: Discovery of novel cGAS inhibitors based on natural flavonoids. 著者: Li, J. / Xiong, M. / Liu, J. / Zhang, F. / Li, M. / Zhao, W. / Xu, Y. |
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履歴 | 登録 | 2023年3月6日 | 登録サイト: PDBJ / 処理サイト: PDBC |
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改定 1.0 | 2024年1月3日 | Provider: repository / タイプ: Initial release |
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