登録情報 | データベース: PDB / ID: 8g20 |
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タイトル | Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with inhibitor Mz327 |
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要素 | Hdac6 protein |
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キーワード | HYDROLASE/INHIBITOR / histone deacetylase / inhibitor / metallohydrolase / hydrolase-inhibitor complex / HYDROLASE |
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機能・相同性 | 機能・相同性情報
tubulin deacetylase activity / swimming behavior / definitive hemopoiesis / protein lysine deacetylase activity / regulation of tubulin deacetylation / histone deacetylase activity / potassium ion binding / histone deacetylase complex / hematopoietic progenitor cell differentiation / epigenetic regulation of gene expression ...tubulin deacetylase activity / swimming behavior / definitive hemopoiesis / protein lysine deacetylase activity / regulation of tubulin deacetylation / histone deacetylase activity / potassium ion binding / histone deacetylase complex / hematopoietic progenitor cell differentiation / epigenetic regulation of gene expression / angiogenesis / negative regulation of transcription by RNA polymerase II / zinc ion binding類似検索 - 分子機能 Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger / Zinc finger, UBP-type / Zn-finger in ubiquitin-hydrolases and other protein / Zinc finger UBP-type profile. / : / Histone deacetylase family / Histone deacetylase domain / Histone deacetylase domain superfamily / Histone deacetylase domain / Ureohydrolase domain superfamily / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 ETHANOL / : / 4-[(N-butylpentanamido)methyl]-N-hydroxybenzamide / Hdac6 protein類似検索 - 構成要素 |
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生物種 | ![](img/tx_fish.gif) Danio rerio (ゼブラフィッシュ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.766 Å |
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データ登録者 | Tararina, M.A. / Christianson, D.W. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM49758 | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2023 タイトル: Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. 著者: Sinatra, L. / Vogelmann, A. / Friedrich, F. / Tararina, M.A. / Neuwirt, E. / Colcerasa, A. / Konig, P. / Toy, L. / Yesiloglu, T.Z. / Hilscher, S. / Gaitzsch, L. / Papenkordt, N. / Zhai, S. / ...著者: Sinatra, L. / Vogelmann, A. / Friedrich, F. / Tararina, M.A. / Neuwirt, E. / Colcerasa, A. / Konig, P. / Toy, L. / Yesiloglu, T.Z. / Hilscher, S. / Gaitzsch, L. / Papenkordt, N. / Zhai, S. / Zhang, L. / Romier, C. / Einsle, O. / Sippl, W. / Schutkowski, M. / Gross, O. / Bendas, G. / Christianson, D.W. / Hansen, F.K. / Jung, M. / Schiedel, M. |
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履歴 | 登録 | 2023年2月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年12月13日 | Provider: repository / タイプ: Initial release |
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