登録情報 | データベース: PDB / ID: 8fal |
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タイトル | Masking thiol reactivity with thioamide-based MBPs- carbonic anhydrase II complexed with benzo[d]thiazole-2(3H)-thione |
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要素 | Carbonic anhydrase 2 |
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キーワード | LYASE / Human Carbonic anhydrases / matrix metalloproteinases / metal binding pharmacophore / fragment based drug discovery |
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機能・相同性 | 機能・相同性情報
positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway ...positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway / positive regulation of synaptic transmission, GABAergic / morphogenesis of an epithelium / carbonic anhydrase / regulation of intracellular pH / carbonate dehydratase activity / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / neuron cellular homeostasis / one-carbon metabolic process / apical part of cell / myelin sheath / zinc ion binding / extracellular exosome / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase類似検索 - ドメイン・相同性 MERCURIBENZOIC ACID / 1,3-benzothiazole-2(3H)-thione / Carbonic anhydrase 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.37 Å |
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データ登録者 | Kohlbrand, A.J. / Seo, H. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01 AI149444 | 米国 |
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引用 | ジャーナル: Chem.Commun.(Camb.) / 年: 2023 タイトル: Masking thiol reactivity with thioamide, thiourea, and thiocarbamate-based MBPs. 著者: Seo, H. / Kohlbrand, A.J. / Stokes, R.W. / Chung, J. / Cohen, S.M. |
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履歴 | 登録 | 2022年11月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年3月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月8日 | Group: Data collection / Structure summary / カテゴリ: chem_comp / chem_comp_atom / chem_comp_bond / Item: _chem_comp.pdbx_synonyms |
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