登録情報 | データベース: PDB / ID: 8emu |
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タイトル | Human Carbonic Anhydrase II Heterobifunctional Degraders |
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要素 | Carbonic anhydrase 2 |
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キーワード | LYASE / targeted protein degrader / PROTAC / metalloenzyme |
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機能・相同性 | 機能・相同性情報
positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / regulation of chloride transport / arylesterase activity / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway ...positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / regulation of chloride transport / arylesterase activity / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway / positive regulation of synaptic transmission, GABAergic / morphogenesis of an epithelium / regulation of intracellular pH / carbonic anhydrase / carbonate dehydratase activity / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / neuron cellular homeostasis / one-carbon metabolic process / apical part of cell / myelin sheath / extracellular exosome / zinc ion binding / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase類似検索 - ドメイン・相同性 MERCURIBENZOIC ACID / N-(2-methoxyethyl)-4-sulfamoylbenzamide / Carbonic anhydrase 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.13 Å |
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データ登録者 | Kohlbrand, A.J. / O'Herin, C.B. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2023 タイトル: Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. 著者: O'Herin, C.B. / Moriuchi, Y.W. / Bemis, T.A. / Kohlbrand, A.J. / Burkart, M.D. / Cohen, S.M. |
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履歴 | 登録 | 2022年9月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年2月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年3月8日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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