登録情報 | データベース: PDB / ID: 8e5n |
---|
タイトル | Structure of ARG1 complex with pyrrolidine-based non-boronic acid inhibitor 10 |
---|
要素 | Arginase-1 |
---|
キーワード | HYDROLASE/INHIBITOR / Arginase / arginine metabolism / urea cycle / HYDROLASE-INHIBITOR complex |
---|
機能・相同性 | 機能・相同性情報
positive regulation of neutrophil mediated killing of fungus / Urea cycle / negative regulation of T-helper 2 cell cytokine production / arginase / arginase activity / arginine catabolic process to ornithine / urea cycle / negative regulation of type II interferon-mediated signaling pathway / defense response to protozoan / negative regulation of activated T cell proliferation ...positive regulation of neutrophil mediated killing of fungus / Urea cycle / negative regulation of T-helper 2 cell cytokine production / arginase / arginase activity / arginine catabolic process to ornithine / urea cycle / negative regulation of type II interferon-mediated signaling pathway / defense response to protozoan / negative regulation of activated T cell proliferation / arginine catabolic process / negative regulation of T cell proliferation / specific granule lumen / azurophil granule lumen / manganese ion binding / adaptive immune response / innate immune response / Neutrophil degranulation / extracellular space / extracellular region / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Arginase / Ureohydrolase, manganese-binding site / Arginase family signature. / Ureohydrolase / Arginase family / Arginase family profile. / Ureohydrolase domain superfamily類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.538 Å |
---|
データ登録者 | Palte, R.L. / Gathiaka, S. |
---|
資金援助 | 1件 |
---|
引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2023 タイトル: Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods. 著者: Gathiaka, S. / Palte, R.L. / So, S.S. / Chai, X. / Richard Miller, J. / Kuvelkar, R. / Wen, X. / Cifelli, S. / Kreamer, A. / Liaw, A. / McLaren, D.G. / Fischer, C. |
---|
履歴 | 登録 | 2022年8月22日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2023年3月8日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年3月15日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.title / _citation_author.name |
---|
改定 1.2 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|