登録情報 | データベース: PDB / ID: 8e3w |
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タイトル | BRD4-D1 in complex with BET inhibitor |
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要素 | Bromodomain-containing protein 4 |
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キーワード | GENE REGULATION/INHIBITOR / bromodomain / BET inhibitor / BRD4 / PET radiotracer / solid tumor imaging / GENE REGULATION-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.47 Å |
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データ登録者 | Gorman, M.A. / Fitzgerald, C.G.D. / White, J.M. / Parker, M.W. |
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資金援助 | 1件 |
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引用 | ジャーナル: Chem.Commun.(Camb.) / 年: 2023 タイトル: Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. 著者: Dickmann, C.G.F. / McDonald, A.F. / Huynh, N. / Rigopoulos, A. / Liu, Z. / Guo, N. / Osellame, L.D. / Gorman, M.A. / Parker, M.W. / Gan, H.K. / Scott, A.M. / Ackermann, U. / Burvenich, I.J.G. / White, J.M. |
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履歴 | 登録 | 2022年8月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年3月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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