Entry | Database: PDB / ID: 8cw2 |
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Title | Crystal structure of TDP1 complexed with compound XZ760 |
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Components | Tyrosyl-DNA phosphodiesterase 1 |
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Keywords | HYDROLASE / phosphodiesterase / DNA BINDING PROTEIN |
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Function / homology | Function and homology information
3'-tyrosyl-DNA phosphodiesterase activity / single strand break repair / Hydrolases; Acting on ester bonds; Phosphoric-diester hydrolases / exonuclease activity / Nonhomologous End-Joining (NHEJ) / double-strand break repair / single-stranded DNA binding / double-stranded DNA binding / intracellular membrane-bounded organelle / DNA repair ...3'-tyrosyl-DNA phosphodiesterase activity / single strand break repair / Hydrolases; Acting on ester bonds; Phosphoric-diester hydrolases / exonuclease activity / Nonhomologous End-Joining (NHEJ) / double-strand break repair / single-stranded DNA binding / double-stranded DNA binding / intracellular membrane-bounded organelle / DNA repair / nucleoplasm / nucleus / plasma membrane / cytoplasmSimilarity search - Function |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.811 Å |
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Authors | Lountos, G.T. / Zhao, X.Z. / Wang, W. / Kiselev, E. / Tropea, J.E. / Needle, D. / Pommier, Y. / Burke, T.R. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | | United States |
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Citation | Journal: Rsc Chem Biol / Year: 2023 Title: Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Authors: Zhao, X.Z. / Wang, W. / Lountos, G.T. / Kiselev, E. / Tropea, J.E. / Needle, D. / Pommier, Y. / Burke Jr., T.R. |
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History | Deposition | May 18, 2022 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Apr 12, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 31, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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Revision 1.2 | Oct 25, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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