登録情報 | データベース: PDB / ID: 8cgw |
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タイトル | Insulin-regulated aminopeptidase (IRAP) in complex with an allosteric benzopyran-based inhibitor |
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要素 | Leucyl-cystinyl aminopeptidase, pregnancy serum form |
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キーワード | HYDROLASE / insulin-regulated aminopeptidase / allosteric inhibitor / benzopyran scaffold / antigen presentation / HFI-419 |
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機能・相同性 | 機能・相同性情報
cystinyl aminopeptidase / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / negative regulation of cold-induced thermogenesis / peptide catabolic process / metalloaminopeptidase activity / aminopeptidase activity / early endosome lumen / Translocation of SLC2A4 (GLUT4) to the plasma membrane / female pregnancy / Endosomal/Vacuolar pathway ...cystinyl aminopeptidase / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / negative regulation of cold-induced thermogenesis / peptide catabolic process / metalloaminopeptidase activity / aminopeptidase activity / early endosome lumen / Translocation of SLC2A4 (GLUT4) to the plasma membrane / female pregnancy / Endosomal/Vacuolar pathway / peptide binding / protein catabolic process / cytoplasmic vesicle membrane / regulation of blood pressure / protein polyubiquitination / metallopeptidase activity / Antigen processing: Ubiquitination & Proteasome degradation / cell-cell signaling / lysosomal membrane / perinuclear region of cytoplasm / signal transduction / proteolysis / extracellular space / zinc ion binding / membrane / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Aminopeptidase N-type / ERAP1-like C-terminal domain / ERAP1-like C-terminal domain / Aminopeptidase N-like , N-terminal domain / Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase / Peptidase M1, membrane alanine aminopeptidase / Peptidase family M1 domain / Peptidase M1 N-terminal domain / Aminopeptidase N-like , N-terminal domain superfamliy / Peptidase M4/M1, CTD superfamily / Neutral zinc metallopeptidases, zinc-binding region signature.類似検索 - ドメイン・相同性 GLYCINE / DI(HYDROXYETHYL)ETHER / Chem-UJX / Leucyl-cystinyl aminopeptidase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.03 Å |
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データ登録者 | Mpakali, A. / Stratikos, E. / Giastas, P. |
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資金援助 | European Union, 1件 組織 | 認可番号 | 国 |
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European Union (EU) | | European Union |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2024 タイトル: Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. 著者: Mpakali, A. / Barla, I. / Lu, L. / Ramesh, K.M. / Thomaidis, N. / Stern, L.J. / Giastas, P. / Stratikos, E. |
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履歴 | 登録 | 2023年2月6日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2024年1月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年2月14日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume / _citation.title |
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