登録情報 データベース : PDB / ID : 8bzp 構造の表示 ダウンロードとリンクタイトル JNK3 (Mitogen-activated protein kinase 10) in Complex with Compound 23 bearing a C(sp3)F2Br moiety 要素Mitogen-activated protein kinase 10 詳細 キーワード TRANSFERASE / Fragment / CF2X / CF2Br / Halogen Bond機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
JUN kinase activity / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / response to light stimulus / mitogen-activated protein kinase / JNK cascade / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / regulation of circadian rhythm / FCERI mediated MAPK activation ... JUN kinase activity / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / response to light stimulus / mitogen-activated protein kinase / JNK cascade / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / regulation of circadian rhythm / FCERI mediated MAPK activation / cellular senescence / rhythmic process / Oxidative Stress Induced Senescence / protein phosphorylation / protein serine kinase activity / signal transduction / mitochondrion / nucleoplasm / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Mitogen-activated protein (MAP) kinase, JNK / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性 BETA-MERCAPTOETHANOL / Chem-C15 / DI(HYDROXYETHYL)ETHER / Chem-SWM / Mitogen-activated protein kinase 10 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.86 Å 詳細データ登録者 Stahlecker, J. / Vaas, S. / Stehle, T. / Boeckler, F.M. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : J.Med.Chem. / 年 : 2023タイトル : Principles and Applications of CF 2 X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery.著者 : Vaas, S. / Zimmermann, M.O. / Schollmeyer, D. / Stahlecker, J. / Engelhardt, M.U. / Rheinganz, J. / Drotleff, B. / Olfert, M. / Lammerhofer, M. / Kramer, M. / Stehle, T. / Boeckler, F.M. 履歴 登録 2022年12月15日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2023年8月2日 Provider : repository / タイプ : Initial release改定 1.1 2023年8月23日 Group : Data collection / Database referencesカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / citation_author Item : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
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