Entry Database : PDB / ID : 7ztl Structure visualization Downloads & linksTitle Crystal structure of a covalently linked Aurora-A N-Myc complex ComponentsAurora kinase A N-myc proto-oncogene protein DetailsKeywords TRANSFERASE / Crosslink / protein-protein-complexFunction / homology Function and homology informationFunction Domain/homology Component
regulation of inner ear auditory receptor cell differentiation / embryonic skeletal system morphogenesis / Interaction between PHLDA1 and AURKA / regulation of centrosome cycle / axon hillock / spindle assembly involved in female meiosis I / cilium disassembly / positive regulation of oocyte maturation / spindle pole centrosome / histone H3S10 kinase activity ... regulation of inner ear auditory receptor cell differentiation / embryonic skeletal system morphogenesis / Interaction between PHLDA1 and AURKA / regulation of centrosome cycle / axon hillock / spindle assembly involved in female meiosis I / cilium disassembly / positive regulation of oocyte maturation / spindle pole centrosome / histone H3S10 kinase activity / chromosome passenger complex / pronucleus / astrocyte differentiation / positive regulation of programmed cell death / meiotic spindle / mitotic centrosome separation / germinal vesicle / protein localization to centrosome / anterior/posterior axis specification / centrosome localization / positive regulation of mesenchymal cell proliferation / neuron projection extension / spindle organization / embryonic digit morphogenesis / cartilage condensation / positive regulation of mitochondrial fission / Signaling by ALK / branching morphogenesis of an epithelial tube / mitotic spindle pole / SUMOylation of DNA replication proteins / negative regulation of astrocyte differentiation / negative regulation of reactive oxygen species metabolic process / spindle midzone / regulation of G2/M transition of mitotic cell cycle / centriole / protein serine/threonine/tyrosine kinase activity / positive regulation of mitotic cell cycle / positive regulation of mitotic nuclear division / AURKA Activation by TPX2 / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / mitotic spindle organization / ciliary basal body / regulation of cytokinesis / regulation of signal transduction by p53 class mediator / negative regulation of protein binding / epithelial cell proliferation / molecular function activator activity / positive regulation of epithelial cell proliferation / liver regeneration / lung development / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 / regulation of protein stability / spindle microtubule / mitotic spindle / kinetochore / kinase binding / positive regulation of miRNA transcription / response to wounding / spindle / G2/M transition of mitotic cell cycle / microtubule cytoskeleton / Regulation of PLK1 Activity at G2/M Transition / sequence-specific double-stranded DNA binding / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / mitotic cell cycle / midbody / DNA-binding transcription activator activity, RNA polymerase II-specific / basolateral plasma membrane / peptidyl-serine phosphorylation / proteasome-mediated ubiquitin-dependent protein catabolic process / Regulation of TP53 Activity through Phosphorylation / protein autophosphorylation / postsynaptic density / protein dimerization activity / non-specific serine/threonine protein kinase / DNA-binding transcription factor activity, RNA polymerase II-specific / protein kinase activity / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / cell division / protein phosphorylation / negative regulation of gene expression / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / glutamatergic synapse / apoptotic process / ubiquitin protein ligase binding / positive regulation of gene expression / chromatin / nucleolus / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / positive regulation of transcription by RNA polymerase II / DNA binding Similarity search - Function Transcription regulator Myc / Transcription regulator Myc, N-terminal / Myc amino-terminal region / Aurora kinase A / Helix-loop-helix DNA-binding domain / Aurora kinase / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. ... Transcription regulator Myc / Transcription regulator Myc, N-terminal / Myc amino-terminal region / Aurora kinase A / Helix-loop-helix DNA-binding domain / Aurora kinase / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Diebold, M. / Schindelin, H. Funding support Germany, 1items Details Hide detailsOrganization Grant number Country German Research Foundation (DFG) GRK2243 Germany
CitationJournal : Acta Crystallogr D Struct Biol / Year : 2023Title : Crystal structure of a covalently linked Aurora-A-MYCN complex.Authors : Diebold, M. / Schonemann, L. / Eilers, M. / Sotriffer, C. / Schindelin, H. History Deposition May 11, 2022 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 18, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Jan 31, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_modelRevision 1.2 Apr 3, 2024 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID
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