登録情報 | データベース: PDB / ID: 7uvb |
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タイトル | CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601 |
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要素 | (Hemoglobin subunit ...) x 2 |
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キーワード | OXYGEN TRANSPORT / metalloprotein / globulin |
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機能・相同性 | 機能・相同性情報
nitric oxide transport / hemoglobin alpha binding / cellular oxidant detoxification / hemoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma ...nitric oxide transport / hemoglobin alpha binding / cellular oxidant detoxification / hemoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / platelet aggregation / hydrogen peroxide catabolic process / oxygen carrier activity / carbon dioxide transport / Late endosomal microautophagy / Heme signaling / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / response to hydrogen peroxide / Cytoprotection by HMOX1 / oxygen binding / regulation of blood pressure / Chaperone Mediated Autophagy / positive regulation of nitric oxide biosynthetic process / tertiary granule lumen / Factors involved in megakaryocyte development and platelet production / blood microparticle / ficolin-1-rich granule lumen / iron ion binding / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosol類似検索 - 分子機能 Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type / : / Globin/Protoglobin / Globin domain profile. / Globin / Globin / Globin-like superfamily類似検索 - ドメイン・相同性 FORMYL GROUP / PROTOPORPHYRIN IX CONTAINING FE / Chem-OHF / Hemoglobin subunit beta / Hemoglobin subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.05 Å |
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データ登録者 | Partridge, J.R. / Kaya, E. / Xu, Q. / Li, Z. / Strutt, S.C. / Cathers, B.E. |
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資金援助 | 1件 |
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引用 | ジャーナル: Br.J.Haematol. / 年: 2023 タイトル: GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. 著者: Dufu, K. / Alt, C. / Strutt, S. / Partridge, J. / Tang, T. / Siu, V. / Liao-Zou, H. / Rademacher, P. / Williams, A.T. / Muller, C.R. / Geng, X. / Pochron, M.P. / Dang, A.N. / Cabrales, P. / ...著者: Dufu, K. / Alt, C. / Strutt, S. / Partridge, J. / Tang, T. / Siu, V. / Liao-Zou, H. / Rademacher, P. / Williams, A.T. / Muller, C.R. / Geng, X. / Pochron, M.P. / Dang, A.N. / Cabrales, P. / Li, Z. / Oksenberg, D. / Cathers, B.E. |
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履歴 | 登録 | 2022年4月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年4月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年7月5日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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