登録情報 | データベース: PDB / ID: 7sho |
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タイトル | Crystal structure of hSTING in complex with c[2',3'-(ara-2'-G, ribo-3'-A)-MP] (RJ242) |
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要素 | Stimulator of interferon genes protein |
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キーワード | IMMUNE SYSTEM / STING / agonist / cGAMP analogs |
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機能・相同性 | 機能・相同性情報
STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ...STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / pattern recognition receptor signaling pathway / reticulophagy / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / antiviral innate immune response / positive regulation of defense response to virus by host / activation of innate immune response / positive regulation of interferon-beta production / Regulation of innate immune responses to cytosolic DNA / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / positive regulation of DNA-binding transcription factor activity / cytoplasmic vesicle membrane / SARS-CoV-1 activates/modulates innate immune responses / regulation of inflammatory response / positive regulation of protein binding / peroxisome / protein complex oligomerization / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / endoplasmic reticulum membrane / Neutrophil degranulation / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / nucleoplasm / identical protein binding / plasma membrane / cytosol類似検索 - 分子機能 : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173類似検索 - ドメイン・相同性 Chem-9UH / Stimulator of interferon genes protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.25 Å |
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データ登録者 | Xie, W. / Lama, L. / Yang, X.J. / Kuryavyi, V. / Nudelman, I. / Glickman, J.F. / Jones, R.A. / Tuschl, T. / Patel, D.J. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | AI141507 | 米国 |
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引用 | ジャーナル: Cell Chem Biol / 年: 2023 タイトル: Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists. 著者: Xie, W. / Lama, L. / Yang, X. / Kuryavyi, V. / Bhattacharya, S. / Nudelman, I. / Yang, G. / Ouerfelli, O. / Glickman, J.F. / Jones, R.A. / Tuschl, T. / Patel, D.J. |
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履歴 | 登録 | 2021年10月10日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年10月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年8月16日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年10月18日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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