- PDB-7s9x: Crystal structure of CDK2 liganded with compound WN378 -
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基本情報
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データベース: PDB / ID: 7s9x
タイトル
Crystal structure of CDK2 liganded with compound WN378
要素
Cyclin-dependent kinase 2
キーワード
CELL CYCLE / allosteric inhibitor / drug development / kinase
機能・相同性
Replication initiator protein RctB, central region / RctB, helix turn helix domain / Vibrionales, replication initiator protein RctB, central region / RctB helix turn helix domain / Chem-8KF / Uncharacterized protein
温度: 291 K / 手法: 蒸気拡散法, ハンギングドロップ法 詳細: 4.5 mg/mL CDK2 crystalized in 50 mM sodium/potassium phosphate, 50 mM HEPES, pH 7.5, 5% v/v PEG3350, soaked overnight in 1 mM WN378 in 50 mM phosphate, 50 mM HEPES Na, 10% v/v PEG3350