登録情報 | データベース: PDB / ID: 7quv |
---|
タイトル | Crystal structure of human Calprotectin (S100A8/S100A9) in complex with Peptide 3 |
---|
要素 | - (Protein S100- ...) x 2
- Peptide 3
|
---|
キーワード | METAL BINDING PROTEIN |
---|
機能・相同性 | 機能・相同性情報
S100A9 complex / regulation of integrin biosynthetic process / sequestering of zinc ion / calprotectin complex / neutrophil aggregation / positive regulation of peptide secretion / regulation of respiratory burst involved in inflammatory response / modulation of process of another organism / autocrine signaling / Toll-like receptor 4 binding ...S100A9 complex / regulation of integrin biosynthetic process / sequestering of zinc ion / calprotectin complex / neutrophil aggregation / positive regulation of peptide secretion / regulation of respiratory burst involved in inflammatory response / modulation of process of another organism / autocrine signaling / Toll-like receptor 4 binding / chronic inflammatory response / peptidyl-cysteine S-trans-nitrosylation / Metal sequestration by antimicrobial proteins / peptide secretion / leukocyte migration involved in inflammatory response / RAGE receptor binding / Regulation of TLR by endogenous ligand / astrocyte development / MyD88 deficiency (TLR2/4) / arachidonic acid binding / intermediate filament cytoskeleton / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / regulation of toll-like receptor signaling pathway / response to zinc ion / regulation of cytoskeleton organization / peptidyl-cysteine S-nitrosylation / antioxidant activity / RHO GTPases Activate NADPH Oxidases / endothelial cell migration / defense response to fungus / positive regulation of intrinsic apoptotic signaling pathway / neutrophil chemotaxis / autophagy / positive regulation of neuron projection development / positive regulation of inflammatory response / antimicrobial humoral immune response mediated by antimicrobial peptide / calcium-dependent protein binding / activation of cysteine-type endopeptidase activity involved in apoptotic process / cell-cell signaling / positive regulation of NF-kappaB transcription factor activity / ER-Phagosome pathway / positive regulation of cell growth / microtubule binding / secretory granule lumen / response to ethanol / collagen-containing extracellular matrix / response to lipopolysaccharide / cytoskeleton / defense response to bacterium / inflammatory response / innate immune response / apoptotic process / calcium ion binding / Neutrophil degranulation / extracellular space / zinc ion binding / extracellular exosome / extracellular region / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 S-100/ICaBP type calcium binding protein signature. / S100/Calcium binding protein 7/8-like, conserved site / S100/CaBP-9k-type, calcium binding, subdomain / S-100/ICaBP type calcium binding domain / S-100/ICaBP type calcium binding domain / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair類似検索 - ドメイン・相同性 Chem-F3U / : / AMINO GROUP / NICKEL (II) ION / TRIETHYLENE GLYCOL / Protein S100-A8 / Protein S100-A9類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.85 Å |
---|
データ登録者 | Diaz-Perlas, C. / Heinis, C. / Pojer, F. / Lau, K. |
---|
資金援助 | スイス, 1件 組織 | 認可番号 | 国 |
---|
Swiss National Science Foundation | | スイス |
|
---|
引用 | ジャーナル: Nat Commun / 年: 2023 タイトル: High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays. 著者: Diaz-Perlas, C. / Ricken, B. / Farrera-Soler, L. / Guschin, D. / Pojer, F. / Lau, K. / Gerhold, C.B. / Heinis, C. |
---|
履歴 | 登録 | 2022年1月19日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2023年2月1日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年8月23日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
---|
改定 1.2 | 2024年2月7日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
---|
|
---|