登録情報 データベース : PDB / ID : 7pav 構造の表示 ダウンロードとリンクタイトル MALT1 in complex with compound 1 要素Mucosa-associated lymphoid tissue lymphoma translocation protein 1 詳細 キーワード TRANSFERASE / Paracaspase / inhibitor complex / CBM complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
polkadots / B-1 B cell differentiation / positive regulation of T-helper 17 cell differentiation / CBM complex / regulation of T cell receptor signaling pathway / response to fungus / CLEC7A/inflammasome pathway / nuclear export / B cell activation / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ... polkadots / B-1 B cell differentiation / positive regulation of T-helper 17 cell differentiation / CBM complex / regulation of T cell receptor signaling pathway / response to fungus / CLEC7A/inflammasome pathway / nuclear export / B cell activation / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / small molecule binding / T cell proliferation / lipopolysaccharide-mediated signaling pathway / positive regulation of interleukin-2 production / proteolysis involved in protein catabolic process / positive regulation of interleukin-1 beta production / positive regulation of protein ubiquitination / Activation of NF-kappaB in B cells / positive regulation of T cell cytokine production / CLEC7A (Dectin-1) signaling / fibrillar center / defense response / FCERI mediated NF-kB activation / ubiquitin-protein transferase activity / Downstream TCR signaling / positive regulation of NF-kappaB transcription factor activity / peptidase activity / T cell receptor signaling pathway / protease binding / regulation of apoptotic process / positive regulation of canonical NF-kappaB signal transduction / endopeptidase activity / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; システインプロテアーゼ / cysteine-type endopeptidase activity / innate immune response / negative regulation of apoptotic process / perinuclear region of cytoplasm / protein-containing complex / proteolysis / identical protein binding / nucleus / cytosol / cytoplasm 類似検索 - 分子機能 : / Mucosa-associated lymphoid tissue lymphoma translocation protein 1 / MALT1, death domain / MALT1 immunoglobulin-like domain / MALT1 Ig-like domain / Immunoglobulin domain / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain ... : / Mucosa-associated lymphoid tissue lymphoma translocation protein 1 / MALT1, death domain / MALT1 immunoglobulin-like domain / MALT1 Ig-like domain / Immunoglobulin domain / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Immunoglobulin domain / Death-like domain superfamily / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold 類似検索 - ドメイン・相同性 Chem-6IO / Mucosa-associated lymphoid tissue lymphoma translocation protein 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.199 Å 詳細データ登録者 Kack, H. / Oster, L. 引用ジャーナル : Eur.J.Med.Chem. / 年 : 2021タイトル : Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors.著者 : Schiesser, S. / Hajek, P. / Pople, H.E. / Kack, H. / Oster, L. / Cox, R.J. 履歴 登録 2021年7月30日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年11月17日 Provider : repository / タイプ : Initial release改定 1.1 2024年1月31日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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