登録情報 | データベース: PDB / ID: 7mhc |
---|
タイトル | Structure of human STING in complex with MK-1454 |
---|
要素 | Stimulator of interferon genes protein |
---|
キーワード | IMMUNE SYSTEM / STING / RECEPTOR / LIGAND COMPLEX / AGONIST / CLOSED CONFORMATION |
---|
機能・相同性 | 機能・相同性情報
STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ...STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / reticulophagy / pattern recognition receptor signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / antiviral innate immune response / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / positive regulation of defense response to virus by host / activation of innate immune response / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / cytoplasmic vesicle membrane / positive regulation of DNA-binding transcription factor activity / peroxisome / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of protein binding / protein complex oligomerization / regulation of inflammatory response / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / plasma membrane / cytosol類似検索 - 分子機能 : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173類似検索 - ドメイン・相同性 Chem-ZEV / Stimulator of interferon genes protein類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.32 Å |
---|
データ登録者 | Lesburg, C.A. |
---|
引用 | ジャーナル: Nature / 年: 2022 タイトル: A kinase-cGAS cascade to synthesize a therapeutic STING activator. 著者: McIntosh, J.A. / Liu, Z. / Andresen, B.M. / Marzijarani, N.S. / Moore, J.C. / Marshall, N.M. / Borra-Garske, M. / Obligacion, J.V. / Fier, P.S. / Peng, F. / Forstater, J.H. / Winston, M.S. / ...著者: McIntosh, J.A. / Liu, Z. / Andresen, B.M. / Marzijarani, N.S. / Moore, J.C. / Marshall, N.M. / Borra-Garske, M. / Obligacion, J.V. / Fier, P.S. / Peng, F. / Forstater, J.H. / Winston, M.S. / An, C. / Chang, W. / Lim, J. / Huffman, M.A. / Miller, S.P. / Tsay, F.R. / Altman, M.D. / Lesburg, C.A. / Steinhuebel, D. / Trotter, B.W. / Cumming, J.N. / Northrup, A. / Bu, X. / Mann, B.F. / Biba, M. / Hiraga, K. / Murphy, G.S. / Kolev, J.N. / Makarewicz, A. / Pan, W. / Farasat, I. / Bade, R.S. / Stone, K. / Duan, D. / Alvizo, O. / Adpressa, D. / Guetschow, E. / Hoyt, E. / Regalado, E.L. / Castro, S. / Rivera, N. / Smith, J.P. / Wang, F. / Crespo, A. / Verma, D. / Axnanda, S. / Dance, Z.E.X. / Devine, P.N. / Tschaen, D. / Canada, K.A. / Bulger, P.G. / Sherry, B.D. / Truppo, M.D. / Ruck, R.T. / Campeau, L.C. / Bennett, D.J. / Humphrey, G.R. / Campos, K.R. / Maddess, M.L. |
---|
履歴 | 登録 | 2021年4月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2022年4月6日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|