登録情報 | データベース: PDB / ID: 7c7b |
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タイトル | Crystal structure of human TRAP1 with SJT009 |
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要素 | Heat shock protein 75 kDa, mitochondrial |
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キーワード | CHAPERONE / TRAP1 / selectivity / mitochondria / Hsp90 / anticancer / drug |
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機能・相同性 | 機能・相同性情報
translational attenuation / negative regulation of cellular respiration / Citric acid cycle (TCA cycle) / tumor necrosis factor receptor binding / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / Respiratory electron transport / negative regulation of reactive oxygen species biosynthetic process / chaperone-mediated protein folding / cell periphery / ATP-dependent protein folding chaperone ...translational attenuation / negative regulation of cellular respiration / Citric acid cycle (TCA cycle) / tumor necrosis factor receptor binding / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / Respiratory electron transport / negative regulation of reactive oxygen species biosynthetic process / chaperone-mediated protein folding / cell periphery / ATP-dependent protein folding chaperone / mitochondrial intermembrane space / unfolded protein binding / protein folding / mitochondrial inner membrane / mitochondrial matrix / protein kinase binding / ATP hydrolysis activity / mitochondrion / RNA binding / nucleoplasm / ATP binding / membrane類似検索 - 分子機能 HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold類似検索 - ドメイン・相同性 Chem-FJX / Heat shock protein 75 kDa, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.5 Å |
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データ登録者 | Kim, D. / Yang, S. / Yoon, N.G. / Park, E. / Kim, S.Y. / Kang, B.H. / Lee, C. / Kang, S. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2021 タイトル: Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. 著者: Yang, S. / Yoon, N.G. / Kim, D. / Park, E. / Kim, S.Y. / Lee, J.H. / Lee, C. / Kang, B.H. / Kang, S. |
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履歴 | 登録 | 2020年5月24日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年5月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年8月25日 | Group: Database references / カテゴリ: citation / citation_author / database_2 Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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