登録情報 | データベース: PDB / ID: 6x5l |
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タイトル | Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors |
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要素 | (Coagulation factor ...) x 2 |
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キーワード | BLOOD CLOTTING / SERINE PROTEASE / ZYMOGEN / HYDROLASE / GLYCOPROTEIN / HYDROXYLATION / PHOSPHOPROTEIN / SULFATION / HEMOSTASIS / HEMOPHILIA / XASE-LIKE VARIANT / COMMUNICATION CHANNEL / GAMMA-CARBOXYGLUTAMIC ACID / EGF-LIKE DOMAIN / DISEASE MUTATION |
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機能・相同性 | 機能・相同性情報
Defective F9 secretion / Defective gamma-carboxylation of F9 / coagulation factor IXa / Defective F9 activation / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / zymogen activation / Extrinsic Pathway of Fibrin Clot Formation / Protein hydroxylation ...Defective F9 secretion / Defective gamma-carboxylation of F9 / coagulation factor IXa / Defective F9 activation / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / zymogen activation / Extrinsic Pathway of Fibrin Clot Formation / Protein hydroxylation / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Removal of aminoterminal propeptides from gamma-carboxylated proteins / Intrinsic Pathway of Fibrin Clot Formation / Golgi lumen / blood coagulation / endopeptidase activity / collagen-containing extracellular matrix / endoplasmic reticulum lumen / serine-type endopeptidase activity / calcium ion binding / proteolysis / extracellular space / extracellular exosome / extracellular region / metal ion binding / plasma membrane類似検索 - 分子機能 : / Peptidase S1A, coagulation factor VII/IX/X/C/Z / Coagulation factor-like, Gla domain superfamily / Laminin / Coagulation Factor Xa inhibitory site / Laminin / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. ...: / Peptidase S1A, coagulation factor VII/IX/X/C/Z / Coagulation factor-like, Gla domain superfamily / Laminin / Coagulation Factor Xa inhibitory site / Laminin / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain superfamily / Vitamin K-dependent carboxylation domain. / Gla domain profile. / Domain containing Gla (gamma-carboxyglutamate) residues. / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ribbon / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 CITRIC ACID / Chem-UQG / Coagulation factor IX類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.246 Å |
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データ登録者 | Jayne, C.L. / Andreani, T. / Chan, T. / Chelliah, M.V. / Clasby, M.C. / Dwyer, M. / Eagen, K.A. / Fried, S. / Greenlee, W.J. / Guo, Z. ...Jayne, C.L. / Andreani, T. / Chan, T. / Chelliah, M.V. / Clasby, M.C. / Dwyer, M. / Eagen, K.A. / Fried, S. / Greenlee, W.J. / Guo, Z. / Hawes, B. / Hruza, A. / Ingram, R. / Keertikar, K.M. / Neelamkavil, S. / Reichert, P. / Xia, Y. / Chackalamannil, S. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2020 タイトル: Discovery of hydroxy pyrimidine Factor IXa inhibitors. 著者: Jayne, C.L. / Andreani, T. / Chan, T.Y. / Chelliah, M.V. / Clasby, M.C. / Dwyer, M. / Eagen, K.A. / Fried, S. / Greenlee, W.J. / Guo, Z. / Hawes, B. / Hruza, A. / Ingram, R. / Keertikar, K.M. ...著者: Jayne, C.L. / Andreani, T. / Chan, T.Y. / Chelliah, M.V. / Clasby, M.C. / Dwyer, M. / Eagen, K.A. / Fried, S. / Greenlee, W.J. / Guo, Z. / Hawes, B. / Hruza, A. / Ingram, R. / Keertikar, K.M. / Neelamkavil, S. / Reichert, P. / Xia, Y. / Chackalamannil, S. |
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履歴 | 登録 | 2020年5月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年6月24日 | Provider: repository / タイプ: Initial release |
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