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Open data
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Basic information
Entry | Database: PDB / ID: 6tg4 | |||||||||
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Title | Tankyrase 2 in complex with an inhibitor (OM-1700) | |||||||||
![]() | Tankyrase-2![]() | |||||||||
![]() | ![]() ![]() ![]() ![]() | |||||||||
Function / homology | ![]() XAV939 stabilizes AXIN / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | |||||||||
Biological species | ![]() ![]() | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | Sowa, S.T. / Lehtio, L. | |||||||||
Funding support | ![]()
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![]() | ![]() Title: Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor. Authors: Waaler, J. / Leenders, R.G.G. / Sowa, S.T. / Alam Brinch, S. / Lycke, M. / Nieczypor, P. / Aertssen, S. / Murthy, S. / Galera-Prat, A. / Damen, E. / Wegert, A. / Nazare, M. / Lehtio, L. / Krauss, S. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 173.2 KB | Display | ![]() |
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PDB format | ![]() | Display | ![]() | |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 6tkmC ![]() 6tknC ![]() 6tkpC ![]() 6tkqC ![]() 6tkrC ![]() 6tksC ![]() 5nobS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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2 | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain: (Details: Chains A B) |
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Components
#1: Protein | ![]() Mass: 27299.764 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() References: UniProt: Q9H2K2, ![]() ![]() #2: Chemical | #3: Chemical | #4: Water | ChemComp-HOH / | ![]() Has ligand of interest | Y | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.28 Å3/Da / Density % sol: 45.96 % |
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Crystal grow![]() | Temperature: 295.15 K / Method: vapor diffusion, sitting drop / Details: 7.5-25% PEG 6000, Bicine, pH = 9.0 |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: Apr 9, 2018 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.76→50 Å / Num. obs: 13394 / % possible obs: 99.5 % / Redundancy: 6.16164 % / CC1/2: 0.979 / Net I/σ(I): 5.33 |
Reflection shell | Resolution: 2.76→2.83 Å / Num. unique obs: 978 / CC1/2: 0.498 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: 5NOB Resolution: 2.76→37.458 Å / Cor.coef. Fo:Fc: 0.917 / Cor.coef. Fo:Fc free: 0.877 / WRfactor Rfree: 0.243 / WRfactor Rwork: 0.2 / SU B: 19.448 / SU ML: 0.353 / Average fsc free: 0.8506 / Average fsc work: 0.8687 / Cross valid method: FREE R-VALUE / ESU R Free: 0.406 Details: Hydrogens have been added in their riding positions
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Solvent computation | Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK BULK SOLVENT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 44.877 Å2
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Refinement step | Cycle: LAST / Resolution: 2.76→37.458 Å
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Refine LS restraints |
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LS refinement shell |
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