Entry | Database: PDB / ID: 6s4a |
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Title | Structure of human MTHFD2 in complex with TH9028 |
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Components | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
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Keywords | OXIDOREDUCTASE |
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Function / homology | Function and homology information
methylenetetrahydrofolate dehydrogenase (NAD+) / methylenetetrahydrofolate dehydrogenase (NAD+) activity / methenyltetrahydrofolate cyclohydrolase / methenyltetrahydrofolate cyclohydrolase activity / methylenetetrahydrofolate dehydrogenase (NADP+) activity / Metabolism of folate and pterines / tetrahydrofolate metabolic process / tetrahydrofolate interconversion / phosphate ion binding / folic acid metabolic process ...methylenetetrahydrofolate dehydrogenase (NAD+) / methylenetetrahydrofolate dehydrogenase (NAD+) activity / methenyltetrahydrofolate cyclohydrolase / methenyltetrahydrofolate cyclohydrolase activity / methylenetetrahydrofolate dehydrogenase (NADP+) activity / Metabolism of folate and pterines / tetrahydrofolate metabolic process / tetrahydrofolate interconversion / phosphate ion binding / folic acid metabolic process / mitochondrial matrix / magnesium ion binding / mitochondrion / extracellular spaceSimilarity search - Function Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. / Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. / Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site / Tetrahydrofolate dehydrogenase/cyclohydrolase / Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain / Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain / Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain / Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain / Aminoacid dehydrogenase-like, N-terminal domain superfamily / NAD(P)-binding domain superfamilySimilarity search - Domain/homology Chem-KUK / NICOTINAMIDE-ADENINE-DINUCLEOTIDE / PHOSPHATE ION / Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialSimilarity search - Component |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.95 Å |
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Authors | Gustafsson, R. / Scaletti, E.R. / Bonagas, N. / Gustafsson, N.M. / Henriksson, M. / Abdurakhmanov, E. / Andersson, Y. / Bengtsson, C. / Borhade, S. / Desroses, M. ...Gustafsson, R. / Scaletti, E.R. / Bonagas, N. / Gustafsson, N.M. / Henriksson, M. / Abdurakhmanov, E. / Andersson, Y. / Bengtsson, C. / Borhade, S. / Desroses, M. / Farnegardh, K. / Garg, N. / Gokturk, C. / Haraldsson, M. / Iliev, P. / Jarvius, M. / Jemth, A.S. / Kalderen, C. / Karsten, S. / Klingegard, F. / Koolmeister, T. / Martens, U. / Llona-Minguez, S. / Loseva, O. / Marttila, P. / Michel, M. / Moulson, R. / Nordstrom, H. / Paulin, C. / Pham, T. / Pudelko, L. / Rasti, A. / Roos, A.K. / Sarno, A. / Sandberg, L. / Scobie, M. / Sjoberg, B. / Svensson, R. / Unterlass, J.E. / Vallin, K. / Vo, D. / Wiita, E. / Warpman-Berglund, U. / Homan, E.J. / Helleday, T. / Stenmark, P. |
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Citation | Journal: Nat Cancer / Year: 2022 Title: Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Authors: Bonagas, N. / Gustafsson, N.M.S. / Henriksson, M. / Marttila, P. / Gustafsson, R. / Wiita, E. / Borhade, S. / Green, A.C. / Vallin, K.S.A. / Sarno, A. / Svensson, R. / Gokturk, C. / Pham, T. ...Authors: Bonagas, N. / Gustafsson, N.M.S. / Henriksson, M. / Marttila, P. / Gustafsson, R. / Wiita, E. / Borhade, S. / Green, A.C. / Vallin, K.S.A. / Sarno, A. / Svensson, R. / Gokturk, C. / Pham, T. / Jemth, A.S. / Loseva, O. / Cookson, V. / Kiweler, N. / Sandberg, L. / Rasti, A. / Unterlass, J.E. / Haraldsson, M. / Andersson, Y. / Scaletti, E.R. / Bengtsson, C. / Paulin, C.B.J. / Sanjiv, K. / Abdurakhmanov, E. / Pudelko, L. / Kunz, B. / Desroses, M. / Iliev, P. / Farnegardh, K. / Kramer, A. / Garg, N. / Michel, M. / Haggblad, S. / Jarvius, M. / Kalderen, C. / Jensen, A.B. / Almlof, I. / Karsten, S. / Zhang, S.M. / Haggblad, M. / Eriksson, A. / Liu, J. / Glinghammar, B. / Nekhotiaeva, N. / Klingegard, F. / Koolmeister, T. / Martens, U. / Llona-Minguez, S. / Moulson, R. / Nordstrom, H. / Parrow, V. / Dahllund, L. / Sjoberg, B. / Vargas, I.L. / Vo, D.D. / Wannberg, J. / Knapp, S. / Krokan, H.E. / Arvidsson, P.I. / Scobie, M. / Meiser, J. / Stenmark, P. / Berglund, U.W. / Homan, E.J. / Helleday, T. |
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History | Deposition | Jun 27, 2019 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 7, 2021 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 11, 2022 | Group: Database references / Refinement description Category: citation / citation_author ...citation / citation_author / database_2 / refine Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine.pdbx_diffrn_id |
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Revision 1.2 | Jun 19, 2024 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond |
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