登録情報 | データベース: PDB / ID: 6qhr |
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タイトル | Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1m |
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要素 | Dual specificity mitogen-activated protein kinase kinase 7 |
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キーワード | TRANSFERASE / Protein Kinase / Kinase / MKK7 |
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機能・相同性 | 機能・相同性情報
JUN kinase kinase activity / regulation of motor neuron apoptotic process / mitogen-activated protein kinase kinase / response to osmotic stress / positive regulation of telomere capping / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / : / Uptake and function of anthrax toxins / MAP kinase activity ...JUN kinase kinase activity / regulation of motor neuron apoptotic process / mitogen-activated protein kinase kinase / response to osmotic stress / positive regulation of telomere capping / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / : / Uptake and function of anthrax toxins / MAP kinase activity / cellular response to interleukin-1 / response to tumor necrosis factor / response to UV / stress-activated MAPK cascade / JNK cascade / positive regulation of JUN kinase activity / positive regulation of telomere maintenance via telomerase / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / molecular function activator activity / FCERI mediated MAPK activation / positive regulation of JNK cascade / response to wounding / cellular senescence / phosphorylation / response to heat / cellular response to lipopolysaccharide / protein phosphatase binding / protein tyrosine kinase activity / Oxidative Stress Induced Senescence / positive regulation of ERK1 and ERK2 cascade / protein serine kinase activity / apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / enzyme binding / magnesium ion binding / signal transduction / ATP binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-J3N / Dual specificity mitogen-activated protein kinase kinase 7類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.52 Å |
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データ登録者 | Wolle, P. / Mueller, M.P. / Rauh, D. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2019 タイトル: Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). 著者: Wolle, P. / Engel, J. / Smith, S. / Goebel, L. / Hennes, E. / Lategahn, J. / Rauh, D. |
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履歴 | 登録 | 2019年1月17日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年5月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年5月29日 | Group: Data collection / Database references / カテゴリ: citation / pdbx_database_proc Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2019年6月5日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity / pdbx_entity_nonpoly Item: _chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.name |
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改定 1.3 | 2019年6月12日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.title / _citation_author.identifier_ORCID |
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改定 1.4 | 2019年6月26日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.5 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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