Entry Database : PDB / ID : 6gxe Structure visualization Downloads & linksTitle Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14 ComponentsCarbonic anhydrase 2 Details Keywords LYASE / Carbonic Anhydrase / CAII mutant to CAIX mimic / CA InhibitorFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway ... positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway / positive regulation of synaptic transmission, GABAergic / morphogenesis of an epithelium / regulation of intracellular pH / carbonic anhydrase / carbonate dehydratase activity / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / neuron cellular homeostasis / one-carbon metabolic process / apical part of cell / myelin sheath / zinc ion binding / extracellular exosome / plasma membrane / cytosol / cytoplasm Similarity search - Function Carbonic Anhydrase II / Alpha carbonic anhydrase / Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase ... Carbonic Anhydrase II / Alpha carbonic anhydrase / Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase / Roll / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.3 Å DetailsAuthors Brynda, J. / Rezacova, P. / Pospisilova, K. Funding support Czech Republic, 1items Details Hide detailsOrganization Grant number Country Czech Science Foundation GA15-05677S Czech Republic
CitationJournal : Acs Omega / Year : 2019Title : Inhibitor-Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase IsoformsAuthors : Pospisilova, K. / Knedlik, T. / Sacha, P. / Kostka, L. / Schimer, J. / Brynda, J. / Kral, V. / Cigler, P. / Navratil, V. / Etrych, T. / Subr, V. / Kugler, M. / Fabry, M. / Rezacova, P. / Konvalinka, J. History Deposition Jun 27, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 8, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Dec 25, 2019 Group : Data collection / Category : reflns_shell / Item : _reflns_shell.percent_possible_allRevision 1.2 May 15, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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