登録情報 | データベース: PDB / ID: 6bfn |
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タイトル | Crystal structure of human IRAK1 |
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要素 | Interleukin-1 receptor-associated kinase 1 |
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キーワード | TRANSFERASE / Interleukin-1 (IL-1) receptor-associated kinases |
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機能・相同性 | 機能・相同性情報
: / regulation of cytokine-mediated signaling pathway / : / : / toll-like receptor 2 signaling pathway / protein serine/threonine kinase activity => GO:0004674 / : / Transcriptional Regulation by MECP2 / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation ...: / regulation of cytokine-mediated signaling pathway / : / : / toll-like receptor 2 signaling pathway / protein serine/threonine kinase activity => GO:0004674 / : / Transcriptional Regulation by MECP2 / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / activation of NF-kappaB-inducing kinase activity / toll-like receptor 9 signaling pathway / positive regulation of leukocyte adhesion to vascular endothelial cell / interleukin-1-mediated signaling pathway / MyD88-dependent toll-like receptor signaling pathway / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / negative regulation of NF-kappaB transcription factor activity / toll-like receptor signaling pathway / type I interferon-mediated signaling pathway / positive regulation of type I interferon production / JNK cascade / lipopolysaccharide-mediated signaling pathway / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / heat shock protein binding / p75NTR recruits signalling complexes / viral process / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / NF-kB is activated and signals survival / response to interleukin-1 / positive regulation of smooth muscle cell proliferation / lipid droplet / positive regulation of MAP kinase activity / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / activated TAK1 mediates p38 MAPK activation / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / positive regulation of non-canonical NF-kappaB signal transduction / cytokine-mediated signaling pathway / Interleukin-1 signaling / PIP3 activates AKT signaling / kinase activity / cellular response to hypoxia / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of NF-kappaB transcription factor activity / positive regulation of canonical NF-kappaB signal transduction / cellular response to heat / cellular response to lipopolysaccharide / protein autophosphorylation / response to lipopolysaccharide / endosome membrane / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / protein heterodimerization activity / protein phosphorylation / protein serine kinase activity / innate immune response / protein serine/threonine kinase activity / negative regulation of apoptotic process / protein homodimerization activity / protein-containing complex / nucleoplasm / ATP binding / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Interleukin-1 receptor-associated kinase 1, death domain / Interleukin-1 receptor-associated kinase 1 / Death domain / Death domain / Death-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 ...Interleukin-1 receptor-associated kinase 1, death domain / Interleukin-1 receptor-associated kinase 1 / Death domain / Death domain / Death-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-DL1 / Interleukin-1 receptor-associated kinase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.26 Å |
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データ登録者 | Wang, L. / Qiao, Q. / Wu, H. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI050872 | 米国 |
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引用 | ジャーナル: Proc. Natl. Acad. Sci. U.S.A. / 年: 2017 タイトル: Crystal structure of human IRAK1. 著者: Wang, L. / Qiao, Q. / Ferrao, R. / Shen, C. / Hatcher, J.M. / Buhrlage, S.J. / Gray, N.S. / Wu, H. |
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履歴 | 登録 | 2017年10月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年12月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年12月20日 | Group: Database references / カテゴリ: citation Item: _citation.journal_abbrev / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2018年1月3日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2024年3月13日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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