登録情報 | データベース: PDB / ID: 5t6g |
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タイトル | 2.45 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7m (hexagonal form) |
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要素 | Genome polyprotein |
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キーワード | PROTEASE/PROTEASE INHIBITOR / PROTEASE / NOROVIRUS / NORWALK VIRUS / ANTIVIRAL INHIBITORS / DIPEPTIDYL INHIBITOR / PROTEASE-PROTEASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
calicivirin / host cell Golgi membrane / ribonucleoside triphosphate phosphatase activity / nucleoside-triphosphate phosphatase / RNA helicase activity / host cell perinuclear region of cytoplasm / host cell endoplasmic reticulum membrane / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity ...calicivirin / host cell Golgi membrane / ribonucleoside triphosphate phosphatase activity / nucleoside-triphosphate phosphatase / RNA helicase activity / host cell perinuclear region of cytoplasm / host cell endoplasmic reticulum membrane / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / DNA-templated transcription / proteolysis / RNA binding / extracellular region / ATP binding / membrane / metal ion binding類似検索 - 分子機能 Viral polyprotein, Caliciviridae N-terminal / Viral polyprotein N-terminal / Norovirus 3C-like protease (NV 3CLpro) domain profile. / Norovirus peptidase C37 / Southampton virus-type processing peptidase / Helicase, superfamily 3, single-stranded RNA virus / Superfamily 3 helicase of positive ssRNA viruses domain profile. / Helicase, superfamily 3, single-stranded DNA/RNA virus / RNA helicase / Trypsin-like serine proteases ...Viral polyprotein, Caliciviridae N-terminal / Viral polyprotein N-terminal / Norovirus 3C-like protease (NV 3CLpro) domain profile. / Norovirus peptidase C37 / Southampton virus-type processing peptidase / Helicase, superfamily 3, single-stranded RNA virus / Superfamily 3 helicase of positive ssRNA viruses domain profile. / Helicase, superfamily 3, single-stranded DNA/RNA virus / RNA helicase / Trypsin-like serine proteases / Thrombin, subunit H / RNA-directed RNA polymerase, C-terminal domain / Viral RNA-dependent RNA polymerase / Reverse transcriptase/Diguanylate cyclase domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / Beta Barrel / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_virus.gif) Norwalk virus (ノロウイルス) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.45 Å |
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データ登録者 | Lovell, S. / Battaile, K.P. / Mehzabeen, N. / Kankanamalage, A.C.G. / Kim, Y. / Rathnayake, A.D. / Damalanka, V.C. / Weerawarna, P.M. / Doyle, S.T. / Alsoudi, A.F. ...Lovell, S. / Battaile, K.P. / Mehzabeen, N. / Kankanamalage, A.C.G. / Kim, Y. / Rathnayake, A.D. / Damalanka, V.C. / Weerawarna, P.M. / Doyle, S.T. / Alsoudi, A.F. / Dissanayake, D.M.P. / Chang, K.-O. / Groutas, W.C. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01AI109039 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | P30GM110761 | 米国 |
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引用 | ジャーナル: Eur J Med Chem / 年: 2016 タイトル: Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. 著者: Galasiti Kankanamalage, A.C. / Kim, Y. / Rathnayake, A.D. / Damalanka, V.C. / Weerawarna, P.M. / Doyle, S.T. / Alsoudi, A.F. / Dissanayake, D.M. / Lushington, G.H. / Mehzabeen, N. / Battaile, ...著者: Galasiti Kankanamalage, A.C. / Kim, Y. / Rathnayake, A.D. / Damalanka, V.C. / Weerawarna, P.M. / Doyle, S.T. / Alsoudi, A.F. / Dissanayake, D.M. / Lushington, G.H. / Mehzabeen, N. / Battaile, K.P. / Lovell, S. / Chang, K.O. / Groutas, W.C. |
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履歴 | 登録 | 2016年9月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年11月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年1月11日 | Group: Database references |
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改定 1.2 | 2017年9月27日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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