登録情報 データベース : PDB / ID : 5pgx 構造の表示 ダウンロードとリンクタイトル CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-(2-BENZYL-6-HYDROXYADAMANTAN-2-YL)-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE 要素Corticosteroid 11-beta-dehydrogenase isozyme 1 詳細 キーワード OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / 11B-HSD1 / SDR / DEHYDROGENASE / HYDROXYSTEROID / INHIBITOR / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBI complex / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
11beta-hydroxysteroid dehydrogenase / 11-beta-hydroxysteroid dehydrogenase (NADP+) activity / cortisol dehydrogenase activity / 7beta-hydroxysteroid dehydrogenase (NADP+) / 7-beta-hydroxysteroid dehydrogenase (NADP+) activity / Glucocorticoid biosynthesis / steroid catabolic process / Prednisone ADME / steroid binding / lung development ... 11beta-hydroxysteroid dehydrogenase / 11-beta-hydroxysteroid dehydrogenase (NADP+) activity / cortisol dehydrogenase activity / 7beta-hydroxysteroid dehydrogenase (NADP+) / 7-beta-hydroxysteroid dehydrogenase (NADP+) activity / Glucocorticoid biosynthesis / steroid catabolic process / Prednisone ADME / steroid binding / lung development / NADP binding / intracellular membrane-bounded organelle / endoplasmic reticulum membrane / protein homodimerization activity / membrane 類似検索 - 分子機能 : / short chain dehydrogenase / Short-chain dehydrogenase/reductase, conserved site / Short-chain dehydrogenases/reductases family signature. / Short-chain dehydrogenase/reductase SDR / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Chem-8KD / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / 11-beta-hydroxysteroid dehydrogenase 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Sheriff, S. 引用ジャーナル : J. Med. Chem. / 年 : 2017タイトル: Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid ... タイトル : Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.著者: Ye, X.Y. / Chen, S.Y. / Wu, S. / Yoon, D.S. / Wang, H. / Hong, Z. / O'Connor, S.P. / Li, J. / Li, J.J. / Kennedy, L.J. / Walker, S.J. / Nayeem, A. / Sheriff, S. / Camac, D.M. / Ramamurthy, V. ... 著者 : Ye, X.Y. / Chen, S.Y. / Wu, S. / Yoon, D.S. / Wang, H. / Hong, Z. / O'Connor, S.P. / Li, J. / Li, J.J. / Kennedy, L.J. / Walker, S.J. / Nayeem, A. / Sheriff, S. / Camac, D.M. / Ramamurthy, V. / Morin, P.E. / Zebo, R. / Taylor, J.R. / Morgan, N.N. / Ponticiello, R.P. / Harrity, T. / Apedo, A. / Golla, R. / Seethala, R. / Wang, M. / Harper, T.W. / Sleczka, B.G. / He, B. / Kirby, M. / Leahy, D.K. / Li, J. / Hanson, R.L. / Guo, Z. / Li, Y.X. / DiMarco, J.D. / Scaringe, R. / Maxwell, B. / Moulin, F. / Barrish, J.C. / Gordon, D.A. / Robl, J.A. 履歴 登録 2017年2月6日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2017年11月1日 Provider : repository / タイプ : Initial release改定 1.1 2018年2月21日 Group : Structure summary / カテゴリ : pdbx_deposit_group / Item : _pdbx_deposit_group.group_type改定 1.2 2024年3月6日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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