登録情報 | データベース: PDB / ID: 5osy |
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タイトル | Human Decapping Scavenger enzyme (hDcpS) in complex with m7G(5'S)ppSp(5'S)G mRNA 5' cap analog |
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要素 | m7GpppX diphosphatase |
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キーワード | HYDROLASE / Protein-ligand complex / decapping / DcpS / m7G(5'S)ppSp(5'S)G / phosphorothiolate / mRNA 5' cap analog / mRNA turnover |
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機能・相同性 | 機能・相同性情報
mRNA methylguanosine-cap decapping / 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase / 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity / mRNA decay by 3' to 5' exoribonuclease / RNA exonuclease activity / : / deadenylation-dependent decapping of nuclear-transcribed mRNA / RNA 7-methylguanosine cap binding / mRNA cis splicing, via spliceosome / nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ...mRNA methylguanosine-cap decapping / 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase / 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity / mRNA decay by 3' to 5' exoribonuclease / RNA exonuclease activity / : / deadenylation-dependent decapping of nuclear-transcribed mRNA / RNA 7-methylguanosine cap binding / mRNA cis splicing, via spliceosome / nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / P-body / mitochondrion / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 mRNA decapping enzyme DcpS N-terminal fold / mRNA decapping enzyme DcpS N-terminal domain / Scavenger mRNA decapping enzyme, N-terminal domain / Scavenger mRNA decapping enzyme DcpS/DCS2 / Scavenger mRNA decapping enzyme, N-terminal / Scavenger mRNA decapping enzyme (DcpS) N-terminal / Scavenger mRNA decapping enzyme C-term binding / Histidine triad, conserved site / HIT domain signature. / HIT-like ...mRNA decapping enzyme DcpS N-terminal fold / mRNA decapping enzyme DcpS N-terminal domain / Scavenger mRNA decapping enzyme, N-terminal domain / Scavenger mRNA decapping enzyme DcpS/DCS2 / Scavenger mRNA decapping enzyme, N-terminal / Scavenger mRNA decapping enzyme (DcpS) N-terminal / Scavenger mRNA decapping enzyme C-term binding / Histidine triad, conserved site / HIT domain signature. / HIT-like / HIT family, subunit A / HIT-like superfamily / Phosphorylase Kinase; domain 1 / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.06 Å |
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データ登録者 | Warminski, M. / Nowak, E. / Wojtczak, B.A. / Fac-Dabrowska, K. / Kubacka, D. / Nowicka, A. / Sikorski, P.J. / Kowalska, J. / Jemielity, J. / Nowotny, M. |
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資金援助 | ポーランド, 2件 組織 | 認可番号 | 国 |
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Ministry of Science and Higher Education | DI2012 024842 | ポーランド | Foundation for Polish Science | TEAM/2016-2/13 | ポーランド |
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引用 | ジャーナル: J. Am. Chem. Soc. / 年: 2018 タイトル: 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. 著者: Wojtczak, B.A. / Sikorski, P.J. / Fac-Dabrowska, K. / Nowicka, A. / Warminski, M. / Kubacka, D. / Nowak, E. / Nowotny, M. / Kowalska, J. / Jemielity, J. |
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履歴 | 登録 | 2017年8月18日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年5月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年5月9日 | Group: Data collection / Database references / カテゴリ: citation / Item: _citation.title |
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改定 1.2 | 2018年5月16日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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