登録情報 | データベース: PDB / ID: 5l6o |
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タイトル | EphB3 kinase domain covalently bound to an irreversible inhibitor (compound 3) |
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要素 | Ephrin type-B receptor 3 |
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キーワード | TRANSFERASE / Kinase / Irreversible Inhibitor / Quinazoline / Signaling |
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機能・相同性 | 機能・相同性情報
urogenital system development / axon guidance receptor activity / central nervous system projection neuron axonogenesis / transmembrane-ephrin receptor activity / digestive tract morphogenesis / regulation of cell-cell adhesion / dendritic spine development / corpus callosum development / ephrin receptor activity / dendritic spine morphogenesis ...urogenital system development / axon guidance receptor activity / central nervous system projection neuron axonogenesis / transmembrane-ephrin receptor activity / digestive tract morphogenesis / regulation of cell-cell adhesion / dendritic spine development / corpus callosum development / ephrin receptor activity / dendritic spine morphogenesis / axonal fasciculation / positive regulation of synapse assembly / EPH-Ephrin signaling / Ephrin signaling / regulation of axonogenesis / retinal ganglion cell axon guidance / regulation of GTPase activity / roof of mouth development / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / EPHB-mediated forward signaling / substrate adhesion-dependent cell spreading / thymus development / axon guidance / receptor protein-tyrosine kinase / cell migration / angiogenesis / protein autophosphorylation / dendrite / extracellular region / ATP binding / plasma membrane / cytosol類似検索 - 分子機能 Ephrin type-B receptor 3, ligand binding domain / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like / : / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain ...Ephrin type-B receptor 3, ligand binding domain / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like / : / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. / Receptor tyrosine kinase class V signature 2. / Eph receptor ligand-binding domain profile. / Ephrin receptor ligand binding domain / Putative ephrin-receptor like / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 1-(4-phenylazanylquinazolin-7-yl)ethanone / 1,4-DIETHYLENE DIOXIDE / Ephrin type-B receptor 3類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.88 Å |
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データ登録者 | Schimpl, M. / Overman, R. / Kung, A. / Chen, Y.-C. / Ni, F. / Zhu, J. / Turner, M. / Molina, H. / Zhang, C. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Science Foundation | CHE-1455306 | 米国 | American Cancer Society | IRG-58-007-51 | 米国 |
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引用 | ジャーナル: J.Am.Chem.Soc. / 年: 2016 タイトル: Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3. 著者: Kung, A. / Chen, Y.C. / Schimpl, M. / Ni, F. / Zhu, J. / Turner, M. / Molina, H. / Overman, R. / Zhang, C. |
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履歴 | 登録 | 2016年5月30日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2016年8月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年9月7日 | Group: Database references |
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改定 1.2 | 2024年1月10日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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