登録情報 データベース : PDB / ID : 5j79 構造の表示 ダウンロードとリンクタイトル The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 Kinase, Compound 3 complex 要素Receptor-interacting serine/threonine-protein kinase 2 詳細 キーワード Transferase/Transferase Inhibitor / kinase domain / kinase inhibitor / structure-based drug design / inhibitor selectivity / Transferase-Transferase Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
response to interleukin-18 / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway / positive regulation of cytokine-mediated signaling pathway / immature T cell proliferation in thymus / positive regulation of T-helper 1 type immune response / positive regulation of xenophagy / LIM domain binding / xenophagy / nucleotide-binding oligomerization domain containing 1 signaling pathway ... response to interleukin-18 / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway / positive regulation of cytokine-mediated signaling pathway / immature T cell proliferation in thymus / positive regulation of T-helper 1 type immune response / positive regulation of xenophagy / LIM domain binding / xenophagy / nucleotide-binding oligomerization domain containing 1 signaling pathway / CD4-positive, alpha-beta T cell proliferation / positive regulation of protein K63-linked ubiquitination / positive regulation of stress-activated MAPK cascade / caspase binding / cellular response to muramyl dipeptide / CARD domain binding / positive regulation of immature T cell proliferation in thymus / JUN kinase kinase kinase activity / cellular response to peptidoglycan / response to interleukin-12 / positive regulation of CD4-positive, alpha-beta T cell proliferation / activation of cysteine-type endopeptidase activity / nucleotide-binding oligomerization domain containing 2 signaling pathway / positive regulation of macrophage cytokine production / toll-like receptor 4 signaling pathway / response to exogenous dsRNA / cellular response to lipoteichoic acid / positive regulation of interferon-alpha production / signaling adaptor activity / canonical NF-kappaB signal transduction / positive regulation of chemokine production / stress-activated MAPK cascade / JNK cascade / lipopolysaccharide-mediated signaling pathway / ERK1 and ERK2 cascade / positive regulation of interleukin-12 production / p75NTR recruits signalling complexes / positive regulation of interleukin-2 production / positive regulation of interferon-beta production / response to interleukin-1 / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / positive regulation of peptidyl-threonine phosphorylation / positive regulation of interleukin-1 beta production / positive regulation of protein ubiquitination / activated TAK1 mediates p38 MAPK activation / positive regulation of JNK cascade / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / protein homooligomerization / cytokine-mediated signaling pathway / Interleukin-1 signaling / positive regulation of interleukin-6 production / positive regulation of type II interferon production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of tumor necrosis factor production / Ovarian tumor domain proteases / phosphorylation / Downstream TCR signaling / positive regulation of protein binding / positive regulation of peptidyl-serine phosphorylation / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / positive regulation of canonical NF-kappaB signal transduction / adaptive immune response / vesicle / positive regulation of ERK1 and ERK2 cascade / cytoskeleton / non-specific serine/threonine protein kinase / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / positive regulation of apoptotic process / innate immune response / protein serine kinase activity / signaling receptor binding / protein serine/threonine kinase activity / apoptotic process / SARS-CoV-2 activates/modulates innate and adaptive immune responses / signal transduction / endoplasmic reticulum / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / ATP binding / identical protein binding / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 Receptor-interacting serine/threonine-protein kinase 2 / RIP2, CARD domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 ... Receptor-interacting serine/threonine-protein kinase 2 / RIP2, CARD domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-6GE / Receptor-interacting serine/threonine-protein kinase 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / フーリエ合成 / 解像度 : 2.69 Å 詳細データ登録者 Convery, M.A. / Casillas, L.N. / Haile, P.A. / Votta, B.J. / Lakdawala, A.S. 引用ジャーナル : J.Med.Chem. / 年 : 2016タイトル : The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.著者: Haile, P.A. / Votta, B.J. / Marquis, R.W. / Bury, M.J. / Mehlmann, J.F. / Singhaus, R. / Charnley, A.K. / Lakdawala, A.S. / Convery, M.A. / Lipshutz, D.B. / Desai, B.M. / Swift, B. / ... 著者 : Haile, P.A. / Votta, B.J. / Marquis, R.W. / Bury, M.J. / Mehlmann, J.F. / Singhaus, R. / Charnley, A.K. / Lakdawala, A.S. / Convery, M.A. / Lipshutz, D.B. / Desai, B.M. / Swift, B. / Capriotti, C.A. / Berger, S.B. / Mahajan, M.K. / Reilly, M.A. / Rivera, E.J. / Sun, H.H. / Nagilla, R. / Beal, A.M. / Finger, J.N. / Cook, M.N. / King, B.W. / Ouellette, M.T. / Totoritis, R.D. / Pierdomenico, M. / Negroni, A. / Stronati, L. / Cucchiara, S. / Ziokowski, B. / Vossenkamper, A. / MacDonald, T.T. / Gough, P.J. / Bertin, J. / Casillas, L.N. 履歴 登録 2016年4月6日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年5月18日 Provider : repository / タイプ : Initial release改定 1.1 2016年6月8日 Group : Database references改定 1.2 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / diffrn_radiation_wavelength / pdbx_initial_refinement_model / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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