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- PDB-5hjp: Identification of LXRbeta selective agonists for the treatment of... -
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Open data
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Basic information
Entry | Database: PDB / ID: 5hjp | ||||||
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Title | Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease | ||||||
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Function / homology | ![]() positive regulation of secretion of lysosomal enzymes / positive regulation of high-density lipoprotein particle assembly / positive regulation of pancreatic juice secretion / phosphatidylcholine acyl-chain remodeling / positive regulation of cholesterol transport / negative regulation of response to endoplasmic reticulum stress / negative regulation of pinocytosis / anatomical structure development / positive regulation of lipoprotein lipase activity / apolipoprotein A-I receptor binding ...positive regulation of secretion of lysosomal enzymes / positive regulation of high-density lipoprotein particle assembly / positive regulation of pancreatic juice secretion / phosphatidylcholine acyl-chain remodeling / positive regulation of cholesterol transport / negative regulation of response to endoplasmic reticulum stress / negative regulation of pinocytosis / anatomical structure development / positive regulation of lipoprotein lipase activity / apolipoprotein A-I receptor binding / positive regulation of triglyceride biosynthetic process / retinoic acid-responsive element binding / NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis / NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose / NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake / positive regulation of lipid storage / NR1H2 & NR1H3 regulate gene expression linked to lipogenesis / positive regulation of fatty acid biosynthetic process / negative regulation of lipid transport / positive regulation of vitamin D receptor signaling pathway / negative regulation of cold-induced thermogenesis / Signaling by Retinoic Acid / nuclear steroid receptor activity / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / negative regulation of type II interferon-mediated signaling pathway / negative regulation of cholesterol storage / negative regulation of macrophage derived foam cell differentiation / positive regulation of cholesterol efflux / retinoic acid receptor signaling pathway / positive regulation of bone mineralization / nuclear retinoid X receptor binding / response to retinoic acid / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / positive regulation of protein metabolic process / VLDLR internalisation and degradation / hormone-mediated signaling pathway / cholesterol homeostasis / negative regulation of proteolysis / RNA polymerase II transcription regulatory region sequence-specific DNA binding / SUMOylation of intracellular receptors / mRNA transcription by RNA polymerase II / PPARA activates gene expression / chromatin DNA binding / positive regulation of miRNA transcription / Nuclear Receptor transcription pathway / RNA polymerase II transcription regulator complex / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Parthasarathy, G. / Klein, D. | ||||||
![]() | ![]() Title: Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease. Authors: Stachel, S.J. / Zerbinatti, C. / Rudd, M.T. / Cosden, M. / Suon, S. / Nanda, K.K. / Wessner, K. / DiMuzio, J. / Maxwell, J. / Wu, Z. / Uslaner, J.M. / Michener, M.S. / Szczerba, P. / ...Authors: Stachel, S.J. / Zerbinatti, C. / Rudd, M.T. / Cosden, M. / Suon, S. / Nanda, K.K. / Wessner, K. / DiMuzio, J. / Maxwell, J. / Wu, Z. / Uslaner, J.M. / Michener, M.S. / Szczerba, P. / Brnardic, E. / Rada, V. / Kim, Y. / Meissner, R. / Wuelfing, P. / Yuan, Y. / Ballard, J. / Holahan, M. / Klein, D.J. / Lu, J. / Fradera, X. / Parthasarathy, G. / Uebele, V.N. / Chen, Z. / Li, Y. / Li, J. / Cooke, A.J. / Bennett, D.J. / Bilodeau, M.T. / Renger, J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 199.9 KB | Display | ![]() |
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PDB format | ![]() | 157.7 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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2 | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 28047.273 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() #2: Protein | Mass: 29968.295 Da / Num. of mol.: 2 / Mutation: Q258A,R260G,D261S,R263S Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() #3: Chemical | #4: Chemical | ![]() #5: Water | ChemComp-HOH / | ![]() |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.13 Å3/Da / Density % sol: 42.33 % |
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Crystal grow![]() | Temperature: 293 K / Method: vapor diffusion, hanging drop / Details: 16% to 22% PEG3350, 0.2M K-Na Tartrate |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 315 / Detector: CCD / Date: Apr 1, 2012 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.6→50 Å / Num. obs: 30577 / % possible obs: 96.8 % / Redundancy: 3.7 % / Net I/σ(I): 16.2 |
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Processing
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Refinement | Resolution: 2.6→35.7 Å / Cor.coef. Fo:Fc: 0.9165 / Cor.coef. Fo:Fc free: 0.875 / Cross valid method: THROUGHOUT / σ(F): 0 / SU Rfree Blow DPI: 0.366
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Displacement parameters | Biso max: 98.51 Å2 / Biso mean: 45.38 Å2 / Biso min: 20.78 Å2
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Refine analyze | Luzzati coordinate error obs: 0.418 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: final / Resolution: 2.6→35.7 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2.6→2.69 Å / Total num. of bins used: 15
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