登録情報 | データベース: PDB / ID: 4zpe |
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タイトル | BACE1 in complex with 4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one |
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要素 | Beta-secretase 1 |
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キーワード | Hydrolase/hydrolase inhibitor / Alzheimer Disease / Amyloid Precursor Protein Secretases / Amyloid beta-Peptides / Aspartic Acid Endopeptidases / Binding Sites / Drug Design / Transgenic / Models / Molecular / Protease Inhibitors / Structure-Activity Relationship / Hydrolase-hydrolase inhibitor complex |
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機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 1.7 Å |
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データ登録者 | Orth, P. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2015 タイトル: Methyl-substitution of an iminohydantoin spiropiperidine beta-secretase (BACE-1) inhibitor has a profound effect on its potency. 著者: Egbertson, M. / McGaughey, G.B. / Pitzenberger, S.M. / Stauffer, S.R. / Coburn, C.A. / Stachel, S.J. / Yang, W. / Barrow, J.C. / Neilson, L.A. / McWherter, M. / Perlow, D. / Fahr, B. / ...著者: Egbertson, M. / McGaughey, G.B. / Pitzenberger, S.M. / Stauffer, S.R. / Coburn, C.A. / Stachel, S.J. / Yang, W. / Barrow, J.C. / Neilson, L.A. / McWherter, M. / Perlow, D. / Fahr, B. / Munshi, S. / Allison, T.J. / Holloway, K. / Selnick, H.G. / Yang, Z. / Swestock, J. / Simon, A.J. / Sankaranarayanan, S. / Colussi, D. / Tugusheva, K. / Lai, M.T. / Pietrak, B. / Haugabook, S. / Jin, L. / Chen, I.W. / Holahan, M. / Stranieri-Michener, M. / Cook, J.J. / Vacca, J. / Graham, S.L. |
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履歴 | 登録 | 2015年5月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年8月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年10月28日 | Group: Database references |
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