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- PDB-4nj3: Modulating the interaction between CDK2 and Cyclin A with a Quino... -
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Open data
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Basic information
Entry | Database: PDB / ID: 4nj3 | ||||||
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Title | Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor | ||||||
![]() | Cyclin-dependent kinase 2![]() | ||||||
![]() | transferase/transferase inhibitor / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() | ||||||
Function / homology | ![]() cyclin A1-CDK2 complex / cyclin E2-CDK2 complex / cyclin E1-CDK2 complex / cyclin A2-CDK2 complex / positive regulation of DNA-templated DNA replication initiation / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Fischmann, T.O. / Hruza, A.W. | ||||||
![]() | ![]() Title: Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. Authors: Deng, Y. / Shipps, G.W. / Zhao, L. / Siddiqui, M.A. / Popovici-Muller, J. / Curran, P.J. / Duca, J.S. / Hruza, A.W. / Fischmann, T.O. / Madison, V.S. / Zhang, R. / McNemar, C.W. / Mayhood, T. ...Authors: Deng, Y. / Shipps, G.W. / Zhao, L. / Siddiqui, M.A. / Popovici-Muller, J. / Curran, P.J. / Duca, J.S. / Hruza, A.W. / Fischmann, T.O. / Madison, V.S. / Zhang, R. / McNemar, C.W. / Mayhood, T.W. / Syto, R. / Annis, A. / Kirschmeier, P. / Lees, E.M. / Parry, D.A. / Windsor, W.T. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 70.5 KB | Display | ![]() |
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PDB format | ![]() | 55.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 34034.527 Da / Num. of mol.: 1 / Fragment: CDK2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() ![]() |
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#2: Chemical | ChemComp-2KD / |
#3: Water | ChemComp-HOH / ![]() |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.08 Å3/Da / Density % sol: 40.75 % |
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Crystal grow![]() | Temperature: 298 K / Method: vapor diffusion, hanging drop / pH: 7.4 Details: 50 MM NA-HEPES, 50 MM, AMMONIUM ACETATE, 8% PEG 4000, 4% GLYCEROL, 1 MM TCEP, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() |
Detector | Type: RIGAKU RAXIS IV++ / Detector: IMAGE PLATE / Date: Apr 21, 2003 / Details: mirrors |
Radiation | Monochromator: MIRRORS / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 1.848→19 Å / Num. all: 24876 / Num. obs: 23588 / % possible obs: 94.8 % / Observed criterion σ(F): 0 / Observed criterion σ(I): 0 |
Reflection shell | Resolution: 1.848→1.87 Å / Rmerge(I) obs: 0.5 / Mean I/σ(I) obs: 1.9 / Num. unique all: 435 / % possible all: 70.3 |
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Processing
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Refinement | Method to determine structure![]() ![]()
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Refinement step | Cycle: LAST / Resolution: 1.848→19 Å
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