登録情報 | データベース: PDB / ID: 3vv6 |
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タイトル | Crystal Structure of beta secetase in complex with 2-amino-3-methyl-6-((1S, 2R)-2-phenylcyclopropyl)pyrimidin-4(3H)-one |
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要素 | Beta-secretase 1 |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / ASPARTYL PROTEASE / BACE / BATA SECRETASE / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / aspartic-type endopeptidase activity / amyloid fibril formation / endosome / endosome membrane / early endosome / lysosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / enzyme binding / cell surface / Golgi apparatus / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.05 Å |
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データ登録者 | Yonezawa, S. / Yamamoto, T. / Yamakawa, H. / Muto, C. / Hosono, M. / Hattori, K. / Higashino, K. / Sakagami, M. / Togame, H. / Tanaka, Y. ...Yonezawa, S. / Yamamoto, T. / Yamakawa, H. / Muto, C. / Hosono, M. / Hattori, K. / Higashino, K. / Sakagami, M. / Togame, H. / Tanaka, Y. / Nakano, T. / Takemoto, H. / Arisawa, M. / Shuto, S. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2012 タイトル: Conformational restriction approach to beta-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode 著者: Yonezawa, S. / Yamamoto, T. / Yamakawa, H. / Muto, C. / Hosono, M. / Hattori, K. / Higashino, K. / Yutsudo, T. / Iwamoto, H. / Kondo, Y. / Sakagami, M. / Togame, H. / Tanaka, Y. / Nakano, T. ...著者: Yonezawa, S. / Yamamoto, T. / Yamakawa, H. / Muto, C. / Hosono, M. / Hattori, K. / Higashino, K. / Yutsudo, T. / Iwamoto, H. / Kondo, Y. / Sakagami, M. / Togame, H. / Tanaka, Y. / Nakano, T. / Takemoto, H. / Arisawa, M. / Shuto, S. |
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履歴 | 登録 | 2012年7月17日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2012年10月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年9月4日 | Group: Database references |
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改定 1.2 | 2017年11月22日 | Group: Refinement description / カテゴリ: software |
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