登録情報 | データベース: PDB / ID: 3sfg |
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タイトル | crystal structure of murine norovirus RNA dependent RNA polymerase in complex with 2thiouridine(2TU) |
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要素 | RNA polymerase |
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キーワード | TRANSFERASE / right hand conformation / POLYMERASE / RNA binding |
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機能・相同性 | 機能・相同性情報
calicivirin / host cell mitochondrion / ribonucleoside triphosphate phosphatase activity / host cell endosome membrane / nucleoside-triphosphate phosphatase / RNA helicase activity / host cell perinuclear region of cytoplasm / host cell endoplasmic reticulum membrane / RNA-directed RNA polymerase / viral RNA genome replication ...calicivirin / host cell mitochondrion / ribonucleoside triphosphate phosphatase activity / host cell endosome membrane / nucleoside-triphosphate phosphatase / RNA helicase activity / host cell perinuclear region of cytoplasm / host cell endoplasmic reticulum membrane / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / DNA-templated transcription / proteolysis / RNA binding / extracellular region / ATP binding / membrane / metal ion binding類似検索 - 分子機能 Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #3230 / Viral polyprotein, Caliciviridae N-terminal / Viral polyprotein N-terminal / Norovirus 3C-like protease (NV 3CLpro) domain profile. / Norovirus peptidase C37 / Southampton virus-type processing peptidase / Mitochondrial Import Receptor Subunit Tom20; Chain A - #20 / Mitochondrial Import Receptor Subunit Tom20; Chain A / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Reverse transcriptase/Diguanylate cyclase domain ...Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #3230 / Viral polyprotein, Caliciviridae N-terminal / Viral polyprotein N-terminal / Norovirus 3C-like protease (NV 3CLpro) domain profile. / Norovirus peptidase C37 / Southampton virus-type processing peptidase / Mitochondrial Import Receptor Subunit Tom20; Chain A - #20 / Mitochondrial Import Receptor Subunit Tom20; Chain A / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Reverse transcriptase/Diguanylate cyclase domain / Helicase, superfamily 3, single-stranded RNA virus / Superfamily 3 helicase of positive ssRNA viruses domain profile. / Helicase, superfamily 3, single-stranded DNA/RNA virus / RNA helicase / Helix non-globular / Special / RNA-directed RNA polymerase, C-terminal domain / Viral RNA-dependent RNA polymerase / Reverse transcriptase/Diguanylate cyclase domain / Alpha-Beta Plaits / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / 2-Layer Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_virus.gif) Murine norovirus 1 (マウスノロウイルス 1) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.209 Å |
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データ登録者 | Kim, K.H. / Alam, I. |
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引用 | ジャーナル: Virology / 年: 2012 タイトル: Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin. 著者: Alam, I. / Lee, J.H. / Cho, K.J. / Han, K.R. / Yang, J.M. / Chung, M.S. / Kim, K.H. |
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履歴 | 登録 | 2011年6月13日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2012年5月9日 | Provider: repository / タイプ: Initial release |
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