登録情報 | データベース: PDB / ID: 3lpi |
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タイトル | Structure of BACE Bound to SCH745132 |
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要素 | Beta-secretase 1 |
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キーワード | HYDROLASE / Alzheimer's / Aspartyl protease |
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機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / aspartic-type endopeptidase activity / amyloid fibril formation / endosome / endosome membrane / early endosome / lysosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / enzyme binding / cell surface / Golgi apparatus / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 L(+)-TARTARIC ACID / Chem-Z74 / Beta-secretase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.05 Å |
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データ登録者 | Strickland, C. / Cumming, J. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2010 タイトル: Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. 著者: Cumming, J. / Babu, S. / Huang, Y. / Carrol, C. / Chen, X. / Favreau, L. / Greenlee, W. / Guo, T. / Kennedy, M. / Kuvelkar, R. / Le, T. / Li, G. / McHugh, N. / Orth, P. / Ozgur, L. / Parker, ...著者: Cumming, J. / Babu, S. / Huang, Y. / Carrol, C. / Chen, X. / Favreau, L. / Greenlee, W. / Guo, T. / Kennedy, M. / Kuvelkar, R. / Le, T. / Li, G. / McHugh, N. / Orth, P. / Ozgur, L. / Parker, E. / Saionz, K. / Stamford, A. / Strickland, C. / Tadesse, D. / Voigt, J. / Zhang, L. / Zhang, Q. |
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履歴 | 登録 | 2010年2月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年4月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2017年11月1日 | Group: Refinement description / カテゴリ: software |
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