登録情報 | データベース: EMDB / ID: EMD-36335 |
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タイトル | Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation |
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マップデータ | |
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試料 | - 細胞: Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab23
- タンパク質・ペプチド: Glutamate receptor ionotropic, NMDA 2A
- タンパク質・ペプチド: Glutamate receptor ionotropic, NMDA 1
- タンパク質・ペプチド: Fab5F6 Heavy Chain
- タンパク質・ペプチド: Fab5F6 Light Chain
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | NMDAR / autoimmune encephalitis / MEMBRANE PROTEIN |
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機能・相同性 | 機能・相同性情報
excitatory chemical synaptic transmission / directional locomotion / Synaptic adhesion-like molecules / serotonin metabolic process / protein localization to postsynaptic membrane / propylene metabolic process / response to glycine / sleep / activation of cysteine-type endopeptidase activity / regulation of monoatomic cation transmembrane transport ...excitatory chemical synaptic transmission / directional locomotion / Synaptic adhesion-like molecules / serotonin metabolic process / protein localization to postsynaptic membrane / propylene metabolic process / response to glycine / sleep / activation of cysteine-type endopeptidase activity / regulation of monoatomic cation transmembrane transport / Assembly and cell surface presentation of NMDA receptors / glutamate receptor signaling pathway / NMDA glutamate receptor activity / Neurexins and neuroligins / NMDA selective glutamate receptor complex / calcium ion transmembrane import into cytosol / glutamate binding / positive regulation of reactive oxygen species biosynthetic process / protein heterotetramerization / glycine binding / positive regulation of calcium ion transport into cytosol / dopamine metabolic process / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / startle response / regulation of neuronal synaptic plasticity / monoatomic cation transmembrane transport / monoatomic cation transport / positive regulation of excitatory postsynaptic potential / Long-term potentiation / ligand-gated monoatomic ion channel activity / excitatory synapse / neurogenesis / positive regulation of synaptic transmission, glutamatergic / calcium ion homeostasis / synaptic cleft / MECP2 regulates neuronal receptors and channels / glutamate-gated calcium ion channel activity / sensory perception of pain / EPHB-mediated forward signaling / response to amphetamine / Ras activation upon Ca2+ influx through NMDA receptor / ionotropic glutamate receptor signaling pathway / regulation of membrane potential / excitatory postsynaptic potential / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / synaptic membrane / synaptic transmission, glutamatergic / negative regulation of protein catabolic process / long-term synaptic potentiation / postsynaptic density membrane / visual learning / cytoplasmic vesicle membrane / protein catabolic process / brain development / regulation of synaptic plasticity / terminal bouton / memory / response to wounding / synaptic vesicle / signaling receptor activity / presynaptic membrane / RAF/MAP kinase cascade / amyloid-beta binding / chemical synaptic transmission / postsynaptic membrane / response to ethanol / learning or memory / dendritic spine / calmodulin binding / postsynaptic density / neuron projection / response to xenobiotic stimulus / positive regulation of apoptotic process / glutamatergic synapse / synapse / dendrite / calcium ion binding / endoplasmic reticulum membrane / protein-containing complex binding / cell surface / positive regulation of transcription by RNA polymerase II / zinc ion binding / plasma membrane / cytoplasm類似検索 - 分子機能 Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel ...Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like I類似検索 - ドメイン・相同性 Glutamate receptor ionotropic, NMDA 1 / Glutamate receptor ionotropic, NMDA 2A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.8 Å |
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データ登録者 | Wang H / Zhu S |
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資金援助 | 中国, 5件 Organization | Grant number | 国 |
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Other government | 2022ZD0212700 | 中国 | Other government | LG 202106-02 | 中国 | Other government | 2017YFA0505700 | 中国 | Other government | XDBS01020000 | 中国 | Other government | 2018SHZDZX05 | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation. 著者: Wang H |
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履歴 | 登録 | 2023年5月29日 | - |
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ヘッダ(付随情報) 公開 | 2024年6月5日 | - |
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マップ公開 | 2024年6月5日 | - |
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更新 | 2024年6月5日 | - |
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現状 | 2024年6月5日 | 処理サイト: PDBj / 状態: 公開 |
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