登録情報 データベース : EMDB / ID : EMD-34520 ダウンロードとリンクタイトル Cryo-EM structure of the human SAGA complex マップデータthis is the main map of the human SAGA complex 詳細 試料複合体 : human SAGA transcriptional coactivator complex 詳細機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
: / : / : / : / : / : / SAGA-type complex / : / regulation of somatic stem cell population maintenance / SAGA complex assembly ... : / : / : / : / : / : / SAGA-type complex / : / regulation of somatic stem cell population maintenance / SAGA complex assembly / lateral mesodermal cell differentiation / allantois development / pre-snoRNP complex / transcription factor TFTC complex / Swr1 complex / SLIK (SAGA-like) complex / regulation of double-strand break repair / splicing factor binding / U12-type spliceosomal complex / negative regulation of microtubule depolymerization / hepatocyte differentiation / positive regulation of response to cytokine stimulus / maintenance of protein location in nucleus / RNA splicing, via transesterification reactions / C2H2 zinc finger domain binding / U2-type spliceosomal complex / U2-type precatalytic spliceosome / U2-type prespliceosome assembly / RNA polymerase binding / box C/D snoRNP assembly / SAGA complex / U2 snRNP / limb development / transcription preinitiation complex / response to L-glutamate / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / NuA4 histone acetyltransferase complex / precatalytic spliceosome / nucleus organization / HIV Transcription Initiation / RNA Polymerase II HIV Promoter Escape / Transcription of the HIV genome / RNA Polymerase II Promoter Escape / RNA Polymerase II Transcription Pre-Initiation And Promoter Opening / RNA Polymerase II Transcription Initiation / RNA Polymerase II Transcription Initiation And Promoter Clearance / mRNA Splicing - Minor Pathway / regulation of RNA splicing / RNA polymerase II transcribes snRNA genes / histone deacetylase complex / MLL1 complex / transcription factor TFIID complex / positive regulation of double-strand break repair via homologous recombination / RNA polymerase II general transcription initiation factor activity / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / histone acetyltransferase complex / embryonic placenta development / positive regulation of transcription initiation by RNA polymerase II / U2 snRNA binding / regulation of DNA repair / somitogenesis / RNA polymerase II preinitiation complex assembly / gastrulation / RNA Polymerase II Pre-transcription Events / visual perception / TBP-class protein binding / catalytic step 2 spliceosome / response to interleukin-1 / mRNA Splicing - Major Pathway / RNA splicing / male germ cell nucleus / DNA-templated transcription initiation / promoter-specific chromatin binding / nuclear estrogen receptor binding / transcription initiation at RNA polymerase II promoter / transcription coregulator activity / Formation of the beta-catenin:TCF transactivating complex / spliceosomal complex / mRNA transcription by RNA polymerase II / multicellular organism growth / negative regulation of protein catabolic process / autophagy / nuclear matrix / cytoplasmic ribonucleoprotein granule / mRNA splicing, via spliceosome / microtubule cytoskeleton organization / G1/S transition of mitotic cell cycle / microtubule cytoskeleton / nucleosome / p53 binding / chromatin organization / HATs acetylate histones / ATPase binding / regulation of apoptotic process / DNA-binding transcription factor binding / Regulation of TP53 Activity through Phosphorylation / transcription by RNA polymerase II / transcription coactivator activity / protein stabilization / transcription cis-regulatory region binding 類似検索 - 分子機能 Transcription-associated protein 1 / STAGA complex 65 subunit gamma / Transcriptional coactivator Hfi1/Transcriptional adapter 1 / Transcriptional regulator of RNA polII, SAGA, subunit / Transcription factor Spt20 / Spt20-like, SEP domain / Spt20, SEP domain / SCA7 domain / SCA7, zinc-binding domain / SCA7 domain profile. ... Transcription-associated protein 1 / STAGA complex 65 subunit gamma / Transcriptional coactivator Hfi1/Transcriptional adapter 1 / Transcriptional regulator of RNA polII, SAGA, subunit / Transcription factor Spt20 / Spt20-like, SEP domain / Spt20, SEP domain / SCA7 domain / SCA7, zinc-binding domain / SCA7 domain profile. / Transcription initiation factor IID, subunit 13 / Transcription initiation factor IID, 18kD subunit / Bromodomain associated / Bromodomain transcription factors and PHD domain containing proteins / Bromodomain associated domain / Transcription initiation factor IID, 31kD subunit / Splicing factor 3B, subunit 5 / Transcription initiation factor TFIID subunit 12 / Transcription initiation factor TFIID subunit A / TFIID subunit TAF5, NTD2 domain superfamily / WD40 associated region in TFIID subunit, NTD2 domain / Transcription initiation factor TAFII31 / TAF6, C-terminal HEAT repeat domain superfamily / TATA box binding protein associated factor (TAF) / Transcription initiation factor TFIID subunit 12 domain / TFIID subunit TAF5, NTD2 domain / Transcription initiation factor TFIID subunit 6 / TAF6 C-terminal HEAT repeat domain / TAF6, C-terminal HEAT repeat domain / Transcription initiation factor TFIID 23-30kDa subunit / Transcription initiation factor TFIID, 23-30kDa subunit / Splicing factor 3B subunit 5/RDS3 complex subunit 10 / Splicing factor 3B subunit 10 (SF3b10) / PIK-related kinase, FAT / FAT domain / FATC / FATC domain / PIK-related kinase / FAT domain profile. / FATC domain profile. / Cleavage/polyadenylation specificity factor, A subunit, N-terminal / Mono-functional DNA-alkylating methyl methanesulfonate N-term / Cleavage/polyadenylation specificity factor, A subunit, C-terminal / CPSF A subunit region / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / TATA box binding protein associated factor / TATA box binding protein associated factor (TAF), histone-like fold domain / Histone-fold / Armadillo-like helical / Armadillo-type fold / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性 Ataxin-7 / Transcription initiation protein SPT3 homolog / TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L / STAGA complex 65 subunit gamma / Transcription initiation factor TFIID subunit 10 / Splicing factor 3B subunit 3 / Transcription initiation factor TFIID subunit 12 / Transcription initiation factor TFIID subunit 9 / Transcription factor SPT20 homolog / Transcriptional adapter 1 ... Ataxin-7 / Transcription initiation protein SPT3 homolog / TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L / STAGA complex 65 subunit gamma / Transcription initiation factor TFIID subunit 10 / Splicing factor 3B subunit 3 / Transcription initiation factor TFIID subunit 12 / Transcription initiation factor TFIID subunit 9 / Transcription factor SPT20 homolog / Transcriptional adapter 1 / Splicing factor 3B subunit 5 / Transformation/transcription domain-associated protein / TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L 類似検索 - 構成要素生物種 Homo sapiens (ヒト) / human (ヒト)手法 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 3.7 Å 詳細 データ登録者Huang J / Zhang Y 資金援助 1件 詳細 詳細を隠すOrganization Grant number 国 Not funded
引用ジャーナル : Cell Discov / 年 : 2022タイトル : Cryo-EM structure of human SAGA transcriptional coactivator complex.著者 : Yuzhu Zhang / Changping Yin / Yue Yin / Mengqi Wei / Wei Jing / Chao Peng / Zhengjun Chen / Jing Huang / 履歴 登録 2022年10月20日 - ヘッダ(付随情報) 公開 2022年12月14日 - マップ公開 2022年12月14日 - 更新 2022年12月14日 - 現状 2022年12月14日 処理サイト : PDBc / 状態 : 公開
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