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- EMDB-33684: The nucleosome-bound human PBAF complex -

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Basic information

Entry
Database: EMDB / ID: EMD-33684
TitleThe nucleosome-bound human PBAF complex
Map dataPBAF overall map
Sample
  • Complex: Nucleosome-bound human PBAF complex
    • Protein or peptide: x 16 types
    • DNA: x 2 types
  • Protein or peptide: x 4 types
  • Ligand: x 3 types
Keywordschromatin remodeling complexes / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex
Function / homology
Function and homology information


single stranded viral RNA replication via double stranded DNA intermediate / positive regulation of glucose mediated signaling pathway / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / bBAF complex / negative regulation of androgen receptor signaling pathway / npBAF complex / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / nBAF complex / brahma complex ...single stranded viral RNA replication via double stranded DNA intermediate / positive regulation of glucose mediated signaling pathway / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / bBAF complex / negative regulation of androgen receptor signaling pathway / npBAF complex / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / nBAF complex / brahma complex / Tat protein binding / blastocyst hatching / GBAF complex / neural retina development / regulation of G0 to G1 transition / N-acetyltransferase activity / EGR2 and SOX10-mediated initiation of Schwann cell myelination / coronary artery morphogenesis / hepatocyte differentiation / regulation of double-strand break repair / Ino80 complex / regulation of nucleotide-excision repair / RSC-type complex / XY body / blastocyst formation / RNA polymerase I preinitiation complex assembly / positive regulation by host of viral transcription / regulation of mitotic metaphase/anaphase transition / SWI/SNF complex / nucleosome disassembly / germ cell nucleus / positive regulation of double-strand break repair / positive regulation of T cell differentiation / cardiac muscle cell proliferation / cellular response to fatty acid / ATP-dependent chromatin remodeler activity / nuclear androgen receptor binding / negative regulation of G1/S transition of mitotic cell cycle / nuclear chromosome / homeostatic process / spinal cord development / NuA4 histone acetyltransferase complex / regulation of chromosome organization / positive regulation of stem cell population maintenance / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / Regulation of MITF-M-dependent genes involved in pigmentation / regulation of DNA replication / regulation of G1/S transition of mitotic cell cycle / regulation of embryonic development / negative regulation of cell differentiation / positive regulation of Wnt signaling pathway / embryonic organ development / positive regulation of myoblast differentiation / positive regulation of double-strand break repair via homologous recombination / ATP-dependent activity, acting on DNA / Chromatin modifying enzymes / regulation of DNA repair / heart morphogenesis / DNA polymerase binding / histone acetyltransferase activity / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Deposition of new CENPA-containing nucleosomes at the centromere / Regulation of TP53 Activity through Acetylation / nucleosomal DNA binding / regulation of mitotic cell cycle / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Inhibition of DNA recombination at telomere / telomere maintenance / Meiotic synapsis / Interleukin-7 signaling / RNA Polymerase I Promoter Opening / positive regulation of DNA repair / Assembly of the ORC complex at the origin of replication / neurogenesis / Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex / transcription initiation-coupled chromatin remodeling / DNA methylation / Condensation of Prophase Chromosomes / SIRT1 negatively regulates rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / HCMV Late Events / negative regulation of cell migration / PRC2 methylates histones and DNA / Regulation of endogenous retroelements by KRAB-ZFP proteins / Defective pyroptosis / transcription coregulator binding / Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) / nuclear receptor binding / HDACs deacetylate histones / helicase activity / positive regulation of cell differentiation / RNA Polymerase I Promoter Escape / transcription elongation by RNA polymerase II / Transcriptional regulation by small RNAs / positive regulation of DNA-binding transcription factor activity / transcription coregulator activity
Similarity search - Function
PHD finger protein 10 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / RFX DNA-binding domain / SWIB domain / SWI complex, BAF60b domains / SMARCC, SWIRM-associated domain / SMARCC, N-terminal / : / SWIRM-associated domain at the N-terminal / SWIRM-associated domain at the C-terminal ...PHD finger protein 10 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / RFX DNA-binding domain / SWIB domain / SWI complex, BAF60b domains / SMARCC, SWIRM-associated domain / SMARCC, N-terminal / : / SWIRM-associated domain at the N-terminal / SWIRM-associated domain at the C-terminal / MarR-like, BRCT and chromo domains module profile. / : / SWI/SNF Subunit INI1, DNA binding domain / : / DNA-binding RFX-type winged-helix domain / SWI/SNF complex subunit BRG1 / RFX-type winged-helix DNA-binding domain profile. / Chromatin-remodeling complex component Sfh1/SNF5 / Protein polybromo-1, Bromodomain 5 / SMARCC, C-terminal / SWIRM-associated region 1 / SNF5/SMARCB1/INI1 / SNF5 / SMARCB1 / INI1 / BRK domain / BRK domain / BRK domain superfamily / domain in transcription and CHROMO domain helicases / Remodelling complex subunit Rsc/polybromo / Protein of unknown function DUF3512 / Domain of unknown function (DUF3512) / Glutamine-Leucine-Glutamine, QLQ / QLQ / QLQ domain profile. / QLQ / : / Snf2-ATP coupling, chromatin remodelling complex / Snf2, ATP coupling domain / Snf2-ATP coupling, chromatin remodelling complex / domain in helicases and associated with SANT domains / HSA domain / Helicase/SANT-associated domain / HSA domain profile. / ARID DNA-binding domain / ARID DNA-binding domain superfamily / ARID/BRIGHT DNA binding domain / ARID domain profile. / BRIGHT, ARID (A/T-rich interaction domain) domain / ARID/BRIGHT DNA binding domain / SWIRM domain / SWIRM domain / SWIRM domain profile. / SWIB/MDM2 domain / Bromo adjacent homology domain / BAH domain / Bromo adjacent homology (BAH) domain / Bromo adjacent homology (BAH) domain superfamily / BAH domain profile. / SWIB/MDM2 domain / SWIB/MDM2 domain profile. / SWIB/MDM2 domain superfamily / SANT domain profile. / SANT domain / HMG (high mobility group) box / Chromo/chromo shadow domain / Chromatin organization modifier domain / HMG boxes A and B DNA-binding domains profile. / high mobility group / High mobility group box domain / High mobility group box domain superfamily / : / SNF2-like, N-terminal domain superfamily / Myb-like DNA-binding domain / SNF2, N-terminal / SNF2-related domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / BRCT domain superfamily / Actin / Actin family / Actin / PHD-finger / Zinc finger C2H2 type domain signature. / Zinc finger PHD-type signature. / Zinc finger C2H2-type / Histone H2B signature. / Histone H2B / Histone H2B / Histone H2A conserved site / Histone H2A signature. / Histone H2A, C-terminal domain / C-terminus of histone H2A / Histone H4, conserved site / Histone H4 signature. / Histone H4 / Histone H4
Similarity search - Domain/homology
Histone H3 / ACTB protein / Histone H4 / Actin-like protein 6A / Transcription activator BRG1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 / AT-rich interactive domain-containing protein 2 / Protein polybromo-1 / SWI/SNF complex subunit SMARCC2 / PHD finger protein 10 ...Histone H3 / ACTB protein / Histone H4 / Actin-like protein 6A / Transcription activator BRG1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 / AT-rich interactive domain-containing protein 2 / Protein polybromo-1 / SWI/SNF complex subunit SMARCC2 / PHD finger protein 10 / Histone H2A type 1-C / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / Bromodomain-containing protein 7 / Histone H2B
Similarity search - Component
Biological speciesHomo sapiens (human)
Methodsingle particle reconstruction / cryo EM / Resolution: 4.4 Å
AuthorsWang L / Yu J / Yu Z / Wang Q / He S / Xu Y
Funding support China, 2 items
OrganizationGrant numberCountry
National Natural Science Foundation of China (NSFC)32030055 China
National Natural Science Foundation of China (NSFC) China
CitationJournal: Nat Commun / Year: 2022
Title: Structure of nucleosome-bound human PBAF complex.
Authors: Li Wang / Jiali Yu / Zishuo Yu / Qianmin Wang / Wanjun Li / Yulei Ren / Zhenguo Chen / Shuang He / Yanhui Xu /
Abstract: BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for transcription activation. ...BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for transcription activation. Despite previous structural studies and recent advance of SWI/SNF family complexes, it remains incompletely understood how PBAF-nucleosome complex is organized. Here we determined structure of 13-subunit human PBAF in complex with acetylated nucleosome in ADP-BeF-bound state. Four PBAF-specific subunits work together with nine BAF/PBAF-shared subunits to generate PBAF-specific modular organization, distinct from that of BAF at various regions. PBAF-nucleosome structure reveals six histone-binding domains and four DNA-binding domains/modules, the majority of which directly bind histone/DNA. This multivalent nucleosome-binding pattern, not observed in previous studies, suggests that PBAF may integrate comprehensive chromatin information to target genomic loci for function. Our study reveals molecular organization of subunits and histone/DNA-binding domains/modules in PBAF-nucleosome complex and provides structural insights into PBAF-mediated nucleosome association complimentary to the recently reported PBAF-nucleosome structure.
History
DepositionJun 24, 2022-
Header (metadata) releaseDec 7, 2022-
Map releaseDec 7, 2022-
UpdateJul 3, 2024-
Current statusJul 3, 2024Processing site: PDBj / Status: Released

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Structure visualization

Supplemental images

emd_33684.png

Downloads & links

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Map

FileDownload / File: emd_33684.map.gz / Format: CCP4 / Size: 178 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
AnnotationPBAF overall map
Projections & slices

Image control

Size
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Others
AxesZ (Sec.)Y (Row.)X (Col.)
1.33 Å/pix.
x 360 pix.
= 480.24 Å		1.33 Å/pix.
x 360 pix.
= 480.24 Å		1.33 Å/pix.
x 360 pix.
= 480.24 Å

Surface

Projections

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Images are generated by Spider.

Voxel sizeX=Y=Z: 1.334 Å
Density

Histogram

Histogram (log scale)
Contour LevelBy AUTHOR: 0.28
Minimum - Maximum-0.6439558 - 1.471982
Average (Standard dev.)-0.0019230427 (±0.053164065)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions360360360
Spacing360360360
CellA=B=C: 480.24 Å
α=β=γ: 90.0 °

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Supplemental data

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Additional map: PBAF ARP module

Fileemd_33684_additional_1.map
AnnotationPBAF ARP module
Projections & Slices
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Additional map: PBAF ATPase module

Fileemd_33684_additional_2.map
AnnotationPBAF ATPase module
Projections & Slices
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Additional map: PBAF base module

Fileemd_33684_additional_3.map
AnnotationPBAF base module
Projections & Slices
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Half map: PBAF overall half map

Fileemd_33684_half_map_1.map
AnnotationPBAF overall half map
Projections & Slices
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Half map: PBAF overall half map

Fileemd_33684_half_map_2.map
AnnotationPBAF overall half map
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Sample components

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Entire : Nucleosome-bound human PBAF complex

EntireName: Nucleosome-bound human PBAF complex
Components
  • Complex: Nucleosome-bound human PBAF complex
    • Protein or peptide: Histone H3
    • Protein or peptide: Histone H4
    • Protein or peptide: Histone H2A type 1-C
    • Protein or peptide: Histone H2B
    • Protein or peptide: ACTB protein (Fragment)
    • Protein or peptide: Actin-like protein 6A
    • Protein or peptide: AT-rich interactive domain-containing protein 2
    • Protein or peptide: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
    • Protein or peptide: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
    • Protein or peptide: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
    • Protein or peptide: PHD finger protein 10
    • Protein or peptide: Bromodomain-containing protein 7
    • Protein or peptide: Unkown
    • Protein or peptide: Protein polybromo-1
    • Protein or peptide: Unknown
    • DNA: DNA (213-MER)
    • DNA: DNA (213-MER)
    • Protein or peptide: Unknown
  • Protein or peptide: Unknown
  • Protein or peptide: Transcription activator BRG1
  • Protein or peptide: SWI/SNF complex subunit SMARCC2
  • Protein or peptide: Unknown
  • Ligand: ADENOSINE-5'-DIPHOSPHATE
  • Ligand: MAGNESIUM ION
  • Ligand: BERYLLIUM TRIFLUORIDE ION

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Supramolecule #1: Nucleosome-bound human PBAF complex

SupramoleculeName: Nucleosome-bound human PBAF complex / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#4, #7-#10, #13-#22
Source (natural)Organism: Homo sapiens (human)

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Macromolecule #1: Histone H3

MacromoleculeName: Histone H3 / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.305969 KDa
Recombinant expressionOrganism: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (bacteria)
SequenceString:
ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSSAV MALQEACEAY LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA

UniProtKB: Histone H3

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Macromolecule #2: Histone H4

MacromoleculeName: Histone H4 / type: protein_or_peptide / ID: 2 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.263231 KDa
Recombinant expressionOrganism: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (bacteria)
SequenceString:
SGRGKGGKGL GKGGAKRHRK VLRDNIQGIT KPAIRRLARR GGVKRISGLI YEETRGVLKV FLENVIRDAV TYTEHAKRKT VTAMDVVYA LKRQGRTLYG FGG

UniProtKB: Histone H4

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Macromolecule #3: Histone H2A type 1-C

MacromoleculeName: Histone H2A type 1-C / type: protein_or_peptide / ID: 3 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 14.004329 KDa
Recombinant expressionOrganism: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (bacteria)
SequenceString:
SGRGKQGGKA RAKAKSRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY LAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK TESHHKAKGK

UniProtKB: Histone H2A type 1-C

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Macromolecule #4: Histone H2B

MacromoleculeName: Histone H2B / type: protein_or_peptide / ID: 4 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 13.806018 KDa
Recombinant expressionOrganism: Escherichia coli 'BL21-Gold(DE3)pLysS AG' (bacteria)
SequenceString:
PEPAKSAPAP KKGSKKAVTK AQKKDGKKRK RSRKESYSVY VYKVLKQVHP DTGISSKAMG IMNSFVNDIF ERIAGEASRL AHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK

UniProtKB: Histone H2B

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Macromolecule #5: Unknown

MacromoleculeName: Unknown / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 2.486056 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

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Macromolecule #6: Transcription activator BRG1

MacromoleculeName: Transcription activator BRG1 / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 184.923828 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPIPTQG PGGYPQDNMH QMHKPMESMH EKGMSDDPR YNQMKGMGMR SGGHAGMGPP PSPMDQHSQG YPSPLGGSEH ASSPVPASGP SSGPQMSSGP GGAPLDGADP Q ALGQQNRG ...String:
MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPIPTQG PGGYPQDNMH QMHKPMESMH EKGMSDDPR YNQMKGMGMR SGGHAGMGPP PSPMDQHSQG YPSPLGGSEH ASSPVPASGP SSGPQMSSGP GGAPLDGADP Q ALGQQNRG PTPFNQNQLH QLRAQIMAYK MLARGQPLPD HLQMAVQGKR PMPGMQQQMP TLPPPSVSAT GPGPGPGPGP GP GPGPAPP NYSRPHGMGG PNMPPPGPSG VPPGMPGQPP GGPPKPWPEG PMANAAAPTS TPQKLIPPQP TGRPSPAPPA VPP AASPVM PPQTQSPGQP AQPAPMVPLH QKQSRITPIQ KPRGLDPVEI LQEREYRLQA RIAHRIQELE NLPGSLAGDL RTKA TIELK ALRLLNFQRQ LRQEVVVCMR RDTALETALN AKAYKRSKRQ SLREARITEK LEKQQKIEQE RKRRQKHQEY LNSIL QHAK DFKEYHRSVT GKIQKLTKAV ATYHANTERE QKKENERIEK ERMRRLMAED EEGYRKLIDQ KKDKRLAYLL QQTDEY VAN LTELVRQHKA AQVAKEKKKK KKKKKAENAE GQTPAIGPDG EPLDETSQMS DLPVKVIHVE SGKILTGTDA PKAGQLE AW LEMNPGYEVA PRSDSEESGS EEEEEEEEEE QPQAAQPPTL PVEEKKKIPD PDSDDVSEVD ARHIIENAKQ DVDDEYGV S QALARGLQSY YAVAHAVTER VDKQSALMVN GVLKQYQIKG LEWLVSLYNN NLNGILADEM GLGKTIQTIA LITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNH HCKLTQVLNT HYVAPRRLLL TGTPLQNKLP ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGEKVDLNEE E TILIIRRL HKVLRPFLLR RLKKEVEAQL PEKVEYVIKC DMSALQRVLY RHMQAKGVLL TDGSEKDKKG KGGTKTLMNT IM QLRKICN HPYMFQHIEE SFSEHLGFTG GIVQGLDLYR ASGKFELLDR ILPKLRATNH KVLLFCQMTS LMTIMEDYFA YRG FKYLRL DGTTKAEDRG MLLKTFNEPG SEYFIFLLST RAGGLGLNLQ SADTVIIFDS DWNPHQDLQA QDRAHRIGQQ NEVR VLRLC TVNSVEEKIL AAAKYKLNVD QKVIQAGMFD QKSSSHERRA FLQAILEHEE QDESRHCSTG SGSASFAHTA PPPAG VNPD LEEPPLKEED EVPDDETVNQ MIARHEEEFD LFMRMDLDRR REEARNPKRK PRLMEEDELP SWIIKDDAEV ERLTCE EEE EKMFGRGSRH RKEVDYSDSL TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR KRDSDAGSST PTTSTRSRDK DDESKKQ KK RGRPPAEKLS PNPPNLTKKM KKIVDAVIKY KDSSSGRQLS EVFIQLPSRK ELPEYYELIR KPVDFKKIKE RIRNHKYR S LNDLEKDVML LCQNAQTFNL EGSLIYEDSI VLQSVFTSVR QKIEKEDDSE GEESEEEEEG EEEGSESESR SVKVKIKLG RKEKAQDRLK GGRRRPSRGS RAKPVVSDDD SEEEQEEDRS GSGSEED

UniProtKB: Transcription activator BRG1

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Macromolecule #7: ACTB protein (Fragment)

MacromoleculeName: ACTB protein (Fragment) / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 41.78266 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV T HTVPIYEG ...String:
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV T HTVPIYEG YALPHAILRL DLAGRDLTDY LMKILTERGY SFTTTAEREI VRDIKEKLCY VALDFEQEMA TAASSSSLEK SY ELPDGQV ITIGNERFRC PEALFQPSFL GMESCGIHET TFNSIMKCDV DIRKDLYANT VLSGGTTMYP GIADRMQKEI TAL APSTMK IKIIAPPERK YSVWIGGSIL ASLSTFQQMW ISKQEYDESG PSIVHRKCF

UniProtKB: ACTB protein

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Macromolecule #8: Actin-like protein 6A

MacromoleculeName: Actin-like protein 6A / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 47.509812 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLK NGMVEDWDSF QAILDHTYKM HVKSEASLHP VLMSEAPWNT RAKREKLTEL MFEHYNIPAF FLCKTAVLTA F ANGRSTGL ...String:
MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLK NGMVEDWDSF QAILDHTYKM HVKSEASLHP VLMSEAPWNT RAKREKLTEL MFEHYNIPAF FLCKTAVLTA F ANGRSTGL ILDSGATHTT AIPVHDGYVL QQGIVKSPLA GDFITMQCRE LFQEMNIELV PPYMIASKEA VREGSPANWK RK EKLPQVT RSWHNYMCNC VIQDFQASVL QVSDSTYDEQ VAAQMPTVHY EFPNGYNCDF GAERLKIPEG LFDPSNVKGL SGN TMLGVS HVVTTSVGMC DIDIRPGLYG SVIVAGGNTL IQSFTDRLNR ELSQKTPPSM RLKLIANNTT VERRFSSWIG GSIL ASLGT FQQMWISKQE YEEGGKQCVE RKCP

UniProtKB: Actin-like protein 6A

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Macromolecule #9: AT-rich interactive domain-containing protein 2

MacromoleculeName: AT-rich interactive domain-containing protein 2 / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 197.581094 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFAL KQYYLRYLEK YEKVHHFGED DDEVPPGNPK PQLPIGAIPS SYNYQQHSVS DYLRQSYGLS MDFNSPNDYN K LVLSLLSG ...String:
MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFAL KQYYLRYLEK YEKVHHFGED DDEVPPGNPK PQLPIGAIPS SYNYQQHSVS DYLRQSYGLS MDFNSPNDYN K LVLSLLSG LPNEVDFAIN VCTLLSNESK HVMQLEKDPK IITLLLANAG VFDDTLGSFS TVFGEEWKEK TDRDFVKFWK DI VDDNEVR DLISDRNKSH EGTSGEWIWE SLFHPPRKLG INDIEGQRVL QIAVILRNLS FEEGNVKLLA ANRTCLRFLL LSA HSHFIS LRQLGLDTLG NIAAELLLDP VDFKTTHLMF HTVTKCLMSR DRFLKMRGME ILGNLCKAED NGVLICEYVD QDSY REIIC HLTLPDVLLV ISTLEVLYML TEMGDVACTK IAKVEKSIDM LVCLVSMDIQ MFGPDALAAV KLIEHPSSSH QMLSE IRPQ AIEQVQTQTH VASAPASRAV VAQHVAPPPG IVEIDSEKFA CQWLNAHFEV NPDCSVSRAE MYSEYLSTCS KLARGG ILT STGFYKCLRT VFPNHTVKRV EDSSSNGQAH IHVVGVKRRA IPLPIQMYYQ QQPVSTSVVR VDSVPDVSPA PSPAGIP HG SQTIGNHFQR TPVANQSSNL TATQMSFPVQ GVHTVAQTVS RIPQNPSPHT HQQQNAPVTV IQSKAPIPCE VVKATVIQ N SIPQTGVPVS IAVGGGPPQS SVVQNHSTGP QPVTVVNSQT LLHHPSVIPQ QSPLHTVVPG QIPSGTPVTV IQQAVPQSH MFGRVQNIPA CTSTVSQGQQ LITTSPQPVQ TSSQQTSAGS QSQDTVIIAP PQYVTTSASN IVSATSVQNF QVATGQMVTI AGVPSPQAS RVGFQNIAPK PLPSQQVSST VVQQPIQQPQ QPTQQSVVIV SQPAQQGQTY APAIHQIVLA NPAALPAGQT V QLTGQPNI TPSSSPSPVP ATNNQVPTAM SSSSTPQSQG PPPTVSQMLS VKRQQQQQHS PAPPPQQVQV QVQQPQQVQM QV QPQQSNA GVGQPASGES SLIKQLLLPK RGPSTPGGKL ILPAPQIPPP NNARAPSPQV VYQVASNQAA GFGVQGQTPA QQL LVGQQN VQLVPSAMPP SGGVQTVPIS NLQILPGPLI SNSPATIFQG TSGNQVTITV VPNTSFAPAT VSQGNATQLI APAG ITMSG TQTGVGLPVQ TLPATQASPA GQSSCTTATP PFKGDKIICQ KEEEAKEATG LHVHERKIEV MENPSCRRGA TNTSN GDTK ENEMHVGSLL NGRKYSDSSL PPSNSGKIQS ETNQCSLISN GPSLELGENG ASGKQNSEQI DMQDIKSDLR KPLVNG ICD FDKGDGSHLS KNIPNHKTSN HVGNGEISPM EPQGTLDITQ QDTAKGDQLE RISNGPVLTL GGSSVSSIQE ASNAATQ QF SGTDLLNGPL ASSLNSDVPQ QRPSVVVSPH STTSVIQGHQ IIAVPDSGSK VSHSPALSSD VRSTNGTAEC KTVKRPAE D TDRETVAGIP NKVGVRIVTI SDPNNAGCSA TMVAVPAGAD PSTVAKVAIE SAVQQKQQHP PTYVQNVVPQ NTPMPPSPA VQVQGQPNSS QPSPFSGSSQ PGDPMRKPGQ NFMCLWQSCK KWFQTPSQVF YHAATEHGGK DVYPGQCLWE GCEPFQRQRF SFITHLQDK HCSKDALLAG LKQDEPGQAG SQKSSTKQPT VGGTSSTPRA QKAIVNHPSA ALMALRRGSR NLVFRDFTDE K EGPITKHI RLTAALILKN IGKYSECGRR LLKRHENNLS VLAISNMEAS STLAKCLYEL NFTVQSKEQE KDSEMLQ

UniProtKB: AT-rich interactive domain-containing protein 2

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Macromolecule #10: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

MacromoleculeName: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 44.199188 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MMMMALSKTF GQKPVKFQLE DDGEFYMIGS EVGNYLRMFR GSLYKRYPSL WRRLATVEER KKIVASSHGK KTKPNTKDHG YTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS QWVPTLPNSS HHLDAVPCST TINRNRMGRD K KRTFPLCF ...String:
MMMMALSKTF GQKPVKFQLE DDGEFYMIGS EVGNYLRMFR GSLYKRYPSL WRRLATVEER KKIVASSHGK KTKPNTKDHG YTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS QWVPTLPNSS HHLDAVPCST TINRNRMGRD K KRTFPLCF DDHDPAVIHE NASQPEVLVP IRLDMEIDGQ KLRDAFTWNM NEKLMTPEMF SEILCDDLDL NPLTFVPAIA SA IRQQIES YPTDSILEDQ SDQRVIIKLN IHVGNISLVD QFEWDMSEKE NSPEKFALKL CSELGLGGEF VTTIAYSIRG QLS WHQKTY AFSENPLPTV EIAIRNTGDA DQWCPLLETL TDAEMEKKIR DQDRNTRRMR RLANTAPAW

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

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Macromolecule #11: SWI/SNF complex subunit SMARCC2

MacromoleculeName: SWI/SNF complex subunit SMARCC2 / type: protein_or_peptide / ID: 11 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 133.048109 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGS LCHILAAAYK FKSDQGWRRY DFQNPSRMDR NVEMFMTIEK SLVQNNCLSR PNIFLCPEIE PKLLGKLKDI I KRHQGTVT ...String:
MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGS LCHILAAAYK FKSDQGWRRY DFQNPSRMDR NVEMFMTIEK SLVQNNCLSR PNIFLCPEIE PKLLGKLKDI I KRHQGTVT EDKNNASHVV YPVPGNLEEE EWVRPVMKRD KQVLLHWGYY PDSYDTWIPA SEIEASVEDA PTPEKPRKVH AK WILDTDT FNEWMNEEDY EVNDDKNPVS RRKKISAKTL TDEVNSPDSD RRDKKGGNYK KRKRSPSPSP TPEAKKKNAK KGP STPYTK SKRGHREEEQ EDLTKDMDEP SPVPNVEEVT LPKTVNTKKD SESAPVKGGT MTDLDEQEDE SMETTGKDED ENST GNKGE QTKNPDLHED NVTEQTHHII IPSYAAWFDY NSVHAIERRA LPEFFNGKNK SKTPEIYLAY RNFMIDTYRL NPQEY LTST ACRRNLAGDV CAIMRVHAFL EQWGLINYQV DAESRPTPMG PPPTSHFHVL ADTPSGLVPL QPKTPQQTSA SQQMLN FPD KGKEKPTDMQ NFGLRTDMYT KKNVPSKSKA AASATREWTE QETLLLLEAL EMYKDDWNKV SEHVGSRTQD ECILHFL RL PIEDPYLEDS EASLGPLAYQ PIPFSQSGNP VMSTVAFLAS VVDPRVASAA AKSALEEFSK MKEEVPTALV EAHVRKVE E AAKVTGKADP AFGLESSGIA GTTSDEPERI EESGNDEARV EGQATDEKKE PKEPREGGGA IEEEAKEKTS EAPKKDEEK GKEGDSEKES EKSDGDPIVD PEKEKEPKEG QEEVLKEVVE SEGERKTKVE RDIGEGNLST AAAAALAAAA VKAKHLAAVE ERKIKSLVA LLVETQMKKL EIKLRHFEEL ETIMDREREA LEYQRQQLLA DRQAFHMEQL KYAEMRARQQ HFQQMHQQQQ Q PPPALPPG SQPIPPTGAA GPPAVHGLAV APASVVPAPA GSGAPPGSLG PSEQIGQAGS TAGPQQQQPA GAPQPGAVPP GV PPPGPHG PSPFPNQQTP PSMMPGAVPG SGHPGVAGNA PLGLPFGMPP PPPPPAPSII PFGSLADSIS INLPAPPNLH GHH HHLPFA PGTLPPPNLP VSMANPLHPN LPATTTMPSS LPLGPGLGSA AAQSPAIVAA VQGNLLPSAS PLPDPGTPLP PDPT APSPG TVTPVPPPQ

UniProtKB: SWI/SNF complex subunit SMARCC2

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Macromolecule #12: Unknown

MacromoleculeName: Unknown / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 1.039273 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)

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Macromolecule #13: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

MacromoleculeName: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 58.311391 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MAARAGFQSV APSGGAGASG GAGAAAALGP GGTPGPPVRM GPAPGQGLYR SPMPGAAYPR PGMLPGSRMT PQGPSMGPPG YGGNPSVRP GLAQSGMDQS RKRPAPQQIQ QVQQQAVQNR NHNAKKKKMA DKILPQRIRE LVPESQAYMD LLAFERKLDQ T IMRKRLDI ...String:
MAARAGFQSV APSGGAGASG GAGAAAALGP GGTPGPPVRM GPAPGQGLYR SPMPGAAYPR PGMLPGSRMT PQGPSMGPPG YGGNPSVRP GLAQSGMDQS RKRPAPQQIQ QVQQQAVQNR NHNAKKKKMA DKILPQRIRE LVPESQAYMD LLAFERKLDQ T IMRKRLDI QEALKRPIKQ KRKLRIFISN TFNPAKSDAE DGEGTVASWE LRVEGRLLED SALSKYDATK QKRKFSSFFK SL VIELDKD LYGPDNHLVE WHRTATTQET DGFQVKRPGD VNVRCTVLLM LDYQPPQFKL DPRLARLLGI HTQTRPVIIQ ALW QYIKTH KLQDPHEREF VICDKYLQQI FESQRMKFSE IPQRLHALLM PPEPIIINHV ISVDPNDQKK TACYDIDVEV DDTL KTQMN SFLLSTASQQ EIATLDNKIH ETIETINQLK TQREFMLSFA RDPQGFINDW LQSQCRDLKT MTDVVGNPEE ERRAE FYFQ PWAQEAVCRY FYSKVQQRRQ ELEQALGIRN T

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

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Macromolecule #14: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

MacromoleculeName: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 46.710371 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNP DLKLWEIGKI IGGMWRDLTD EEKQEYLNEY EAEKIEYNES MKAYHNSPAY LAYINAKSRA EAALEEESRQ R QSRMEKGE ...String:
MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNP DLKLWEIGKI IGGMWRDLTD EEKQEYLNEY EAEKIEYNES MKAYHNSPAY LAYINAKSRA EAALEEESRQ R QSRMEKGE PYMSIQPAED PDDYDDGFSM KHTATARFQR NHRLISEILS ESVVPDVRSV VTTARMQVLK RQVQSLMVHQ RK LEAELLQ IEERHQEKKR KFLESTDSFN NELKRLCGLK VEVDMEKIAA EIAQAEEQAR KRQEEREKEA AEQAERSQSS IVP EEEQAA NKGEEKKDDE NIPMETEETH LEETTESQQN GEEGTSTPED KESGQEGVDS MAEEGTSDSN TGSESNSATV EEPP TDPIP EDEKKE

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

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Macromolecule #15: PHD finger protein 10

MacromoleculeName: PHD finger protein 10 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 56.131855 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS SQDLGFSYYP AENLIEYKWP PDETGEYYM LQEQVSEYLG VTSFKRKYPD LERRDLSHKE KLYLRELNVI TETQCTLGLT ALRSDEVIDL MIKEYPAKHA E YSVILQEK ...String:
MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS SQDLGFSYYP AENLIEYKWP PDETGEYYM LQEQVSEYLG VTSFKRKYPD LERRDLSHKE KLYLRELNVI TETQCTLGLT ALRSDEVIDL MIKEYPAKHA E YSVILQEK ERQRITDHYK EYSQMQQQNT QKVEASKVPE YIKKAAKKAA EFNSNLNRER MEERRAYFDL QTHVIQVPQG KY KVLPTER TKVSSYPVAL IPGQFQEYYK RYSPDELRYL PLNTALYEPP LDPELPALDS DGDSDDGEDG RGDEKRKNKG TSD SSSGNV SEGESPPDSQ EDSFQGRQKS KDKAATPRKD GPKRSVLSKS VPGYKPKVIP NAICGICLKG KESNKKGKAE SLIH CSQCE NSGHPSCLDM TMELVSMIKT YPWQCMECKT CIICGQPHHE EEMMFCDMCD RGYHTFCVGL GAIPSGRWIC DCCQR APPT PRKVGRRGKN SKEG

UniProtKB: PHD finger protein 10

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Macromolecule #16: Bromodomain-containing protein 7

MacromoleculeName: Bromodomain-containing protein 7 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 74.257688 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD RKRKKRKKGE KQIPGEEKGR KRRRVKEDK KKRDRDRVEN EAEKDLQCHA PVRLDLPPEK PLTSSLAKQE EVEQTPLQEA LNQLMRQLQR KDPSAFFSFP V TDFIAPGY ...String:
MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD RKRKKRKKGE KQIPGEEKGR KRRRVKEDK KKRDRDRVEN EAEKDLQCHA PVRLDLPPEK PLTSSLAKQE EVEQTPLQEA LNQLMRQLQR KDPSAFFSFP V TDFIAPGY SMIIKHPMDF STMKEKIKNN DYQSIEELKD NFKLMCTNAM IYNKPETIYY KAAKKLLHSG MKILSQERIQ SL KQSIDFM ADLQKTRKQK DGTDTSQSGE DGGCWQRERE DSGDAEAHAF KSPSKENKKK DKDMLEDKFK SNNLEREQEQ LDR IVKESG GKLTRRLVNS QCEFERRKPD GTTTLGLLHP VDPIVGEPGY CPVRLGMTTG RLQSGVNTLQ GFKEDKRNKV TPVL YLNYG PYSSYAPHYD STFANISKDD SDLIYSTYGE DSDLPSDFSI HEFLATCQDY PYVMADSLLD VLTKGGHSRT LQEME MSLP EDEGHTRTLD TAKEMEITEV EPPGRLDSST QDRLIALKAV TNFGVPVEVF DSEEAEIFQK KLDETTRLLR ELQEAQ NER LSTRPPPNMI CLLGPSYREM HLAEQVTNNL KELAQQVTPG DIVSTYGVRK AMGISIPSPV MENNFVDLTE DTEEPKK TD VAECGPGGS

UniProtKB: Bromodomain-containing protein 7

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Macromolecule #17: Unkown

MacromoleculeName: Unkown / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 1.890321 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)

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Macromolecule #18: Protein polybromo-1

MacromoleculeName: Protein polybromo-1 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 184.157281 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY KDEQGRLLCE LFIRAPKRRN QPDYYEVVS QPIDLMKIQQ KLKMEEYDDV NLLTADFQLL FNNAKSYYKP DSPEYKAACK LWDLYLRTRN EFVQKGEADD E DDDEDGQD ...String:
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY KDEQGRLLCE LFIRAPKRRN QPDYYEVVS QPIDLMKIQQ KLKMEEYDDV NLLTADFQLL FNNAKSYYKP DSPEYKAACK LWDLYLRTRN EFVQKGEADD E DDDEDGQD NQGTVTEGSS PAYLKEILEQ LLEAIVVATN PSGRLISELF QKLPSKVQYP DYYAIIKEPI DLKTIAQRIQ NG SYKSIHA MAKDIDLLAK NAKTYNEPGS QVFKDANSIK KIFYMKKAEI EHHEMAKSSL RMRTPSNLAA ARLTGPSHSK GSL GEERNP TSKYYRNKRA VQGGRLSAIT MALQYGSESE EDAALAAARY EEGESEAESI TSFMDVSNPF YQLYDTVRSC RNNQ GQLIA EPFYHLPSKK KYPDYYQQIK MPISLQQIRT KLKNQEYETL DHLECDLNLM FENAKRYNVP NSAIYKRVLK LQQVM QAKK KELARRDDIE DGDSMISSAT SDTGSAKRKR NTHDSEMLGL RRLSSKKNIR KQRMKILFNV VLEAREPGSG RRLCDL FMV KPSKKDYPDY YKIILEPMDL KIIEHNIRND KYAGEEGMIE DMKLMFRNAR HYNEEGSQVY NDAHILEKLL KEKRKEL GP LPDDDDMASP KLKLSRKSGI SPKKSKYMTP MQQKLNEVYE AVKNYTDKRG RRLSAIFLRL PSRSELPDYY LTIKKPMD M EKIRSHMMAN KYQDIDSMVE DFVMMFNNAC TYNEPESLIY KDALVLHKVL LETRRDLEGD EDSHVPNVTL LIQELIHNL FVSVMSHQDD EGRCYSDSLA EIPAVDPNFP NKPPLTFDII RKNVENNRYR RLDLFQEHMF EVLERARRMN RTDSEIYEDA VELQQFFIK IRDELCKNGE ILLSPALSYT TKHLHNDVEK ERKEKLPKEI EEDKLKREEE KREAEKSEDS SGAAGLSGLH R TYSQDCSF KNSMYHVGDY VYVEPAEANL QPHIVCIERL WEDSAGEKWL YGCWFYRPNE TFHLATRKFL EKEVFKSDYY NK VPVSKIL GKCVVMFVKE YFKLCPENFR DEDVFVCESR YSAKTKSFKK IKLWTMPISS VRFVPRDVPL PVVRVASVFA NAD KGDDEK NTDNSEDSRA EDNFNLEKEK EDVPVEMSNG EPGCHYFEQL HYNDMWLKVG DCVFIKSHGL VRPRVGRIEK VWVR DGAAY FYGPIFIHPE ETEHEPTKMF YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP ENDILLCESR YNESD KQMK KFKGLKRFSL SAKVVDDEIY YFRKPIVPQK EPSPLLEKKI QLLEAKFAEL EGGDDDIEEM GEEDSEVIEP PSLPQL QTP LASELDLMPY TPPQSTPKSA KGSAKKEGSK RKINMSGYIL FSSEMRAVIK AQHPDYSFGE LSRLVGTEWR NLETAKK AE YEGVMNQGVA PMVGTPAPGG SPYGQQVGVL GPPGQQAPPP YPGPHPAGPP VIQQPTTPMF VAPPPKTQRL LHSEAYLK Y IEGLSAESNS ISKWDQTLAA RRRDVHLSKE QESRLPSHWL KSKGAHTTMA DALWRLRDLM LRDTLNIRQA YNLENV

UniProtKB: Protein polybromo-1

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Macromolecule #19: Unknown

MacromoleculeName: Unknown / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 8.698714 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) ...String:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

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Macromolecule #22: Unknown

MacromoleculeName: Unknown / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 2.060531 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)

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Macromolecule #20: DNA (213-MER)

MacromoleculeName: DNA (213-MER) / type: dna / ID: 20 / Number of copies: 1 / Classification: DNA
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 65.534699 KDa
SequenceString: (DA)(DT)(DC)(DC)(DT)(DG)(DG)(DG)(DG)(DA) (DA)(DT)(DT)(DC)(DC)(DC)(DT)(DG)(DG)(DA) (DG)(DA)(DA)(DT)(DC)(DC)(DC)(DG)(DG) (DT)(DG)(DC)(DC)(DG)(DA)(DG)(DG)(DC)(DC) (DG) (DC)(DT)(DC)(DA)(DA)(DT) ...String:
(DA)(DT)(DC)(DC)(DT)(DG)(DG)(DG)(DG)(DA) (DA)(DT)(DT)(DC)(DC)(DC)(DT)(DG)(DG)(DA) (DG)(DA)(DA)(DT)(DC)(DC)(DC)(DG)(DG) (DT)(DG)(DC)(DC)(DG)(DA)(DG)(DG)(DC)(DC) (DG) (DC)(DT)(DC)(DA)(DA)(DT)(DT)(DG) (DG)(DT)(DC)(DG)(DT)(DA)(DG)(DA)(DC)(DA) (DG)(DC) (DT)(DC)(DT)(DA)(DG)(DC)(DA) (DC)(DC)(DG)(DC)(DT)(DT)(DA)(DA)(DA)(DC) (DG)(DC)(DA) (DC)(DG)(DT)(DA)(DC)(DG) (DC)(DG)(DC)(DT)(DG)(DT)(DC)(DC)(DC)(DC) (DC)(DG)(DC)(DG) (DT)(DT)(DT)(DT)(DA) (DA)(DC)(DC)(DG)(DC)(DC)(DA)(DA)(DG)(DG) (DG)(DG)(DA)(DT)(DT) (DA)(DC)(DT)(DC) (DC)(DC)(DT)(DA)(DG)(DT)(DC)(DT)(DC)(DC) (DA)(DG)(DG)(DC)(DA)(DC) (DG)(DT)(DG) (DT)(DC)(DA)(DC)(DA)(DT)(DA)(DT)(DA)(DT) (DA)(DC)(DA)(DT)(DC)(DC)(DT) (DG)(DT) (DT)(DC)(DC)(DA)(DG)(DT)(DG)(DC)(DC)(DG) (DG)(DT)(DG)(DT)(DC)(DG)(DC)(DT) (DT) (DG)(DG)(DG)(DT)(DC)(DC)(DC)(DG)(DA)(DG) (DG)(DA)(DT)(DT)(DA)(DC)(DA)(DA)(DG) (DC)(DT)(DT)(DA)(DT)(DC)(DG)(DA)(DT)(DA) (DG)(DA)(DT)

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Macromolecule #21: DNA (213-MER)

MacromoleculeName: DNA (213-MER) / type: dna / ID: 21 / Number of copies: 1 / Classification: DNA
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 65.998055 KDa
SequenceString: (DA)(DT)(DC)(DT)(DA)(DT)(DC)(DG)(DA)(DT) (DA)(DA)(DG)(DC)(DT)(DT)(DG)(DT)(DA)(DA) (DT)(DC)(DC)(DT)(DC)(DG)(DG)(DG)(DA) (DC)(DC)(DC)(DA)(DA)(DG)(DC)(DG)(DA)(DC) (DA) (DC)(DC)(DG)(DG)(DC)(DA) ...String:
(DA)(DT)(DC)(DT)(DA)(DT)(DC)(DG)(DA)(DT) (DA)(DA)(DG)(DC)(DT)(DT)(DG)(DT)(DA)(DA) (DT)(DC)(DC)(DT)(DC)(DG)(DG)(DG)(DA) (DC)(DC)(DC)(DA)(DA)(DG)(DC)(DG)(DA)(DC) (DA) (DC)(DC)(DG)(DG)(DC)(DA)(DC)(DT) (DG)(DG)(DA)(DA)(DC)(DA)(DG)(DG)(DA)(DT) (DG)(DT) (DA)(DT)(DA)(DT)(DA)(DT)(DG) (DT)(DG)(DA)(DC)(DA)(DC)(DG)(DT)(DG)(DC) (DC)(DT)(DG) (DG)(DA)(DG)(DA)(DC)(DT) (DA)(DG)(DG)(DG)(DA)(DG)(DT)(DA)(DA)(DT) (DC)(DC)(DC)(DC) (DT)(DT)(DG)(DG)(DC) (DG)(DG)(DT)(DT)(DA)(DA)(DA)(DA)(DC)(DG) (DC)(DG)(DG)(DG)(DG) (DG)(DA)(DC)(DA) (DG)(DC)(DG)(DC)(DG)(DT)(DA)(DC)(DG)(DT) (DG)(DC)(DG)(DT)(DT)(DT) (DA)(DA)(DG) (DC)(DG)(DG)(DT)(DG)(DC)(DT)(DA)(DG)(DA) (DG)(DC)(DT)(DG)(DT)(DC)(DT) (DA)(DC) (DG)(DA)(DC)(DC)(DA)(DA)(DT)(DT)(DG)(DA) (DG)(DC)(DG)(DG)(DC)(DC)(DT)(DC) (DG) (DG)(DC)(DA)(DC)(DC)(DG)(DG)(DG)(DA)(DT) (DT)(DC)(DT)(DC)(DC)(DA)(DG)(DG)(DG) (DA)(DA)(DT)(DT)(DC)(DC)(DC)(DC)(DA)(DG) (DG)(DA)(DT)

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Macromolecule #23: ADENOSINE-5'-DIPHOSPHATE

MacromoleculeName: ADENOSINE-5'-DIPHOSPHATE / type: ligand / ID: 23 / Number of copies: 1 / Formula: ADP
Molecular weightTheoretical: 427.201 Da
Chemical component information

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

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Macromolecule #24: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 24 / Number of copies: 1 / Formula: MG
Molecular weightTheoretical: 24.305 Da

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Macromolecule #25: BERYLLIUM TRIFLUORIDE ION

MacromoleculeName: BERYLLIUM TRIFLUORIDE ION / type: ligand / ID: 25 / Number of copies: 1 / Formula: BEF
Molecular weightTheoretical: 66.007 Da
Chemical component information

ChemComp-BEF:
BERYLLIUM TRIFLUORIDE ION

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

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Sample preparation

BufferpH: 8
VitrificationCryogen name: ETHANE

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Electron microscopy

MicroscopeFEI TITAN KRIOS
Image recordingFilm or detector model: GATAN K3 (6k x 4k) / Average electron dose: 50.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: OTHER / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.5 µm / Nominal defocus min: 1.0 µm
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Startup modelType of model: NONE
Final reconstructionResolution.type: BY AUTHOR / Resolution: 4.4 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 37528
Initial angle assignmentType: MAXIMUM LIKELIHOOD
Final angle assignmentType: MAXIMUM LIKELIHOOD

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