登録情報 | データベース: EMDB / ID: EMD-32436 |
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タイトル | Human TRPC5 channel in complex with riluzole |
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マップデータ | sharpened map |
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試料 | - 複合体: human transient receptor potential channel 5 tetramer
- タンパク質・ペプチド: Short transient receptor potential channel 5
- リガンド: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
- リガンド: CHOLESTEROL HEMISUCCINATE
- リガンド: ZINC ION
- リガンド: CALCIUM ION
- リガンド: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
- リガンド: PHOSPHATIDYLETHANOLAMINE
- リガンド: [3-[(~{E})-octadec-10-enoyl]oxy-2-oxidanyl-propyl] (~{E})-octadec-10-enoate
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機能・相同性 | 機能・相同性情報
regulation of membrane hyperpolarization / phosphatidylserine exposure on apoptotic cell surface / negative regulation of dendrite morphogenesis / Role of second messengers in netrin-1 signaling / store-operated calcium channel activity / cation channel complex / inositol 1,4,5 trisphosphate binding / actinin binding / TRP channels / clathrin binding ...regulation of membrane hyperpolarization / phosphatidylserine exposure on apoptotic cell surface / negative regulation of dendrite morphogenesis / Role of second messengers in netrin-1 signaling / store-operated calcium channel activity / cation channel complex / inositol 1,4,5 trisphosphate binding / actinin binding / TRP channels / clathrin binding / positive regulation of axon extension / regulation of cytosolic calcium ion concentration / calcium channel complex / positive regulation of neuron differentiation / positive regulation of peptidyl-threonine phosphorylation / calcium ion transmembrane transport / calcium channel activity / neuron differentiation / calcium ion transport / ATPase binding / nervous system development / actin binding / positive regulation of cytosolic calcium ion concentration / growth cone / neuron apoptotic process / neuronal cell body / positive regulation of cell population proliferation / dendrite / plasma membrane類似検索 - 分子機能 Transient receptor potential channel, canonical 5 / Transient receptor ion channel II / Transient receptor ion channel domain / Transient receptor ion channel II / Transient receptor potential channel, canonical / Ankyrin repeat / Ankyrin repeats (3 copies) / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily ...Transient receptor potential channel, canonical 5 / Transient receptor ion channel II / Transient receptor ion channel domain / Transient receptor ion channel II / Transient receptor potential channel, canonical / Ankyrin repeat / Ankyrin repeats (3 copies) / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Ion transport domain / Ion transport protein類似検索 - ドメイン・相同性 Short transient receptor potential channel 5類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.4 Å |
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データ登録者 | Chen L / Wei M / Yang Y |
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資金援助 | 中国, 4件 Organization | Grant number | 国 |
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National Natural Science Foundation of China (NSFC) | 91957201 | 中国 | National Natural Science Foundation of China (NSFC) | 31870833 | 中国 | National Science Foundation (NSF, China) | 31821091 | 中国 | National Science Foundation (NSF, China) | 11902021 | 中国 |
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引用 | ジャーナル: Cell Discov / 年: 2022 タイトル: Structural identification of riluzole-binding site on human TRPC5. 著者: Yaxiong Yang / Miao Wei / Lei Chen / ![](img/flg_china.gif) |
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履歴 | 登録 | 2021年12月21日 | - |
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ヘッダ(付随情報) 公開 | 2022年4月13日 | - |
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マップ公開 | 2022年4月13日 | - |
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更新 | 2022年8月3日 | - |
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現状 | 2022年8月3日 | 処理サイト: PDBj / 状態: 公開 |
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