- EMDB-28795: Voltage-gated potassium channel Kv3.1 apo -
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基本情報
登録情報
データベース: EMDB / ID: EMD-28795
タイトル
Voltage-gated potassium channel Kv3.1 apo
マップデータ
試料
複合体: potassium voltage-gated channel
タンパク質・ペプチド: Potassium voltage-gated channel subfamily C member 1
リガンド: ZINC ION
リガンド: CHOLESTEROL
リガンド: POTASSIUM ION
キーワード
ion channel / positive modulator / voltage gated / voltage gated potassium channel / TRANSPORT PROTEIN
機能・相同性
機能・相同性情報
response to nerve growth factor / globus pallidus development / response to light intensity / response to potassium ion / response to fibroblast growth factor / response to auditory stimulus / corpus callosum development / positive regulation of potassium ion transmembrane transport / voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / Voltage gated Potassium channels ...response to nerve growth factor / globus pallidus development / response to light intensity / response to potassium ion / response to fibroblast growth factor / response to auditory stimulus / corpus callosum development / positive regulation of potassium ion transmembrane transport / voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / Voltage gated Potassium channels / delayed rectifier potassium channel activity / optic nerve development / neuronal cell body membrane / response to amine / voltage-gated potassium channel activity / kinesin binding / calyx of Held / axolemma / axon terminus / potassium ion transmembrane transport / voltage-gated potassium channel complex / dendrite membrane / cerebellum development / protein tetramerization / potassium ion transport / protein homooligomerization / response to toxic substance / cellular response to xenobiotic stimulus / presynaptic membrane / postsynaptic membrane / transmembrane transporter binding / cell surface / plasma membrane 類似検索 - 分子機能
Potassium channel, voltage dependent, Kv3.1 / Potassium channel, voltage dependent, Kv3 / Potassium channel, voltage dependent, Kv / Potassium channel tetramerisation-type BTB domain / BTB/POZ domain / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / Voltage-dependent channel domain superfamily / SKP1/BTB/POZ domain superfamily / Ion transport domain / Ion transport protein 類似検索 - ドメイン・相同性
Potassium voltage-gated channel subfamily C member 1 類似検索 - 構成要素
ジャーナル: Proc Natl Acad Sci U S A / 年: 2023 タイトル: Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels. 著者: Yun-Ting Chen / Mee Ra Hong / Xin-Jun Zhang / James Kostas / Yuxing Li / Richard L Kraus / Vincent P Santarelli / Deping Wang / Yacob Gomez-Llorente / Alexei Brooun / Corey Strickland / ...著者: Yun-Ting Chen / Mee Ra Hong / Xin-Jun Zhang / James Kostas / Yuxing Li / Richard L Kraus / Vincent P Santarelli / Deping Wang / Yacob Gomez-Llorente / Alexei Brooun / Corey Strickland / Stephen M Soisson / Daniel J Klein / Anthony T Ginnetti / Michael J Marino / Shawn J Stachel / Andrii Ishchenko / 要旨: Voltage-gated potassium channels (Kv) are tetrameric membrane proteins that provide a highly selective pathway for potassium ions (K) to diffuse across a hydrophobic cell membrane. These unique ...Voltage-gated potassium channels (Kv) are tetrameric membrane proteins that provide a highly selective pathway for potassium ions (K) to diffuse across a hydrophobic cell membrane. These unique voltage-gated cation channels detect changes in membrane potential and, upon activation, help to return the depolarized cell to a resting state during the repolarization stage of each action potential. The Kv3 family of potassium channels is characterized by a high activation potential and rapid kinetics, which play a crucial role for the fast-spiking neuronal phenotype. Mutations in the Kv3.1 channel have been shown to have implications in various neurological diseases like epilepsy and Alzheimer's disease. Moreover, disruptions in neuronal circuitry involving Kv3.1 have been correlated with negative symptoms of schizophrenia. Here, we report the discovery of a novel positive modulator of Kv3.1, investigate its biophysical properties, and determine the cryo-EM structure of the compound in complex with Kv3.1. Structural analysis reveals the molecular determinants of positive modulation in Kv3.1 channels by this class of compounds and provides additional opportunities for rational drug design for the treatment of associated neurological disorders.