HETEROGEN S-adenosylmethionine synthetase catalyzes the reaction of: AMPPNP + Met -----> SAM + PPNP ...HETEROGEN S-adenosylmethionine synthetase catalyzes the reaction of: AMPPNP + Met -----> SAM + PPNP In the crystal structure, the authors found that two subunits (A, B) contain the substrates (AMPPNP and Met) and the other two subunits (C, D) have the products (SAM and PPNP) in their active sites. In the PDB file, the authors used ANP as AMPPNP, SAM as S-adenosylmethionine, and PPK as PPNP.
The enzyme is a homo-tetramer, and the asymmetric unit contains a tetramer.
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Components
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Protein , 1 types, 4 molecules ABCD
#1: Protein
S-adenosylmethioninesynthetase / Methionine adenosyltransferase / AdoMet synthetase / MAT
Mass: 41867.309 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Escherichia coli (E. coli) Gene: METK OR METX OR B2942 OR C3528 OR Z4287 OR ECS3818 OR SF2933 Production host: Escherichia coli (E. coli) / References: UniProt: P0A817, methionine adenosyltransferase
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