Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex
Map data
primary map
Sample
Complex: OTR in complex with Oxytocin, heterotrimeric mini-Gq chimera (Goqi) and scFv16
Complex: Heterotrimeric mini-Gq chimera (Goqi) and Oxytocin receptor
Protein or peptide: Guanine nucleotide-binding protein G(o) subunit alpha,cDNA FLJ31446 fis, clone NT2NE2000909, highly similar to Guanine nucleotide-binding protein G(o) subunit alpha 1
Protein or peptide: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Protein or peptide: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Protein or peptide: Oxytocin receptor
Complex: Oxytocin
Protein or peptide: Oxytocin
Complex: Antibody fragment scFv16
Protein or peptide: Antibody fragment scFv16
Function / homology
Function and homology information
oxytocin receptor activity / positive regulation of hindgut contraction / response to anoxia / maternal aggressive behavior / oxytocin receptor binding / neurohypophyseal hormone activity / V1A vasopressin receptor binding / guanyl nucleotide binding / Vasopressin-like receptors / regulation of systemic arterial blood pressure by vasopressin ...oxytocin receptor activity / positive regulation of hindgut contraction / response to anoxia / maternal aggressive behavior / oxytocin receptor binding / neurohypophyseal hormone activity / V1A vasopressin receptor binding / guanyl nucleotide binding / Vasopressin-like receptors / regulation of systemic arterial blood pressure by vasopressin / vasopressin receptor activity / positive regulation of penile erection / maternal process involved in parturition / response to prostaglandin E / positive regulation of uterine smooth muscle contraction / positive regulation of norepinephrine secretion / negative regulation of urine volume / sperm ejaculation / response to sucrose / telencephalon development / drinking behavior / positive regulation of prostaglandin secretion / grooming behavior / response to ether / mu-type opioid receptor binding / corticotropin-releasing hormone receptor 1 binding / positive regulation of blood pressure / maternal behavior / neuropeptide hormone activity / positive regulation of ossification / digestive tract development / vesicle docking involved in exocytosis / positive regulation of synapse assembly / positive regulation of female receptivity / response to food / G protein-coupled dopamine receptor signaling pathway / regulation of heart contraction / eating behavior / male mating behavior / suckling behavior / peptide hormone binding / microvillus / positive regulation of vasoconstriction / social behavior / estrous cycle / negative regulation of insulin secretion / positive regulation of synaptic transmission / G protein-coupled serotonin receptor binding / positive regulation of synaptic transmission, glutamatergic / muscle contraction / response to electrical stimulus / response to retinoic acid / response to glucocorticoid / cellular response to hormone stimulus / response to cAMP / response to amphetamine / ERK1 and ERK2 cascade / negative regulation of blood pressure / lactation / regulation of heart rate / peptide binding / secretory granule / response to cocaine / response to activity / response to cytokine / locomotory behavior / response to progesterone / positive regulation of synaptic transmission, GABAergic / female pregnancy / adherens junction / G-protein beta/gamma-subunit complex binding / Olfactory Signaling Pathway / Activation of the phototransduction cascade / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / G beta:gamma signalling through PLC beta / Presynaptic function of Kainate receptors / Thromboxane signalling through TP receptor / terminal bouton / G protein-coupled acetylcholine receptor signaling pathway / G-protein activation / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / Prostacyclin signalling through prostacyclin receptor / Glucagon signaling in metabolic regulation / G beta:gamma signalling through CDC42 / memory / response to peptide hormone / ADP signalling through P2Y purinoceptor 12 / G beta:gamma signalling through BTK / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Sensory perception of sweet, bitter, and umami (glutamate) taste / photoreceptor disc membrane / Adrenaline,noradrenaline inhibits insulin secretion / Glucagon-type ligand receptors / Vasopressin regulates renal water homeostasis via Aquaporins / G alpha (z) signalling events / cellular response to catecholamine stimulus / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / ADORA2B mediated anti-inflammatory cytokines production / sensory perception of taste Similarity search - Function
Journal: Nat Commun / Year: 2022 Title: Structural basis for the activation and ligand recognition of the human oxytocin receptor. Authors: Yann Waltenspühl / Janosch Ehrenmann / Santiago Vacca / Cristian Thom / Ohad Medalia / Andreas Plückthun / Abstract: The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo- ...The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo-electron microscopy structure of the active oxytocin receptor (OTR) in complex with its cognate ligand oxytocin. Our structure provides high-resolution insights into the OT binding mode, the OTR activation mechanism as well as the subtype specificity within the oxytocin/vasopressin receptor family.
Entire : OTR in complex with Oxytocin, heterotrimeric mini-Gq chimera (Goq...
Entire
Name: OTR in complex with Oxytocin, heterotrimeric mini-Gq chimera (Goqi) and scFv16
Components
Complex: OTR in complex with Oxytocin, heterotrimeric mini-Gq chimera (Goqi) and scFv16
Complex: Heterotrimeric mini-Gq chimera (Goqi) and Oxytocin receptor
Protein or peptide: Guanine nucleotide-binding protein G(o) subunit alpha,cDNA FLJ31446 fis, clone NT2NE2000909, highly similar to Guanine nucleotide-binding protein G(o) subunit alpha 1
Protein or peptide: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Protein or peptide: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Protein or peptide: Oxytocin receptor
Complex: Oxytocin
Protein or peptide: Oxytocin
Complex: Antibody fragment scFv16
Protein or peptide: Antibody fragment scFv16
+
Supramolecule #1: OTR in complex with Oxytocin, heterotrimeric mini-Gq chimera (Goq...
Supramolecule
Name: OTR in complex with Oxytocin, heterotrimeric mini-Gq chimera (Goqi) and scFv16 type: complex / Chimera: Yes / ID: 1 / Parent: 0 / Macromolecule list: all
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Supramolecule #2: Heterotrimeric mini-Gq chimera (Goqi) and Oxytocin receptor
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