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Structure paper

TitleTemperature and intrinsic Ca2+ reshape TRPM4 pharmacology
Journal, issue, pagesTo Be Published
Publish dateNov 4, 2025 (structure data deposition date)
AuthorsJinhong H / Sofia I / Sung Jin P / Junuk L / Jennifer C / Garrett O / Jiangnan S / Juan D / Wei L
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.51 - 3.1 Å
Structure data

73754

9z1w

EMDB-73754, PDB-9z1w:
Cryo-EM structure of human TRPM4 channel in complex with calcium and TPPO at 37 degrees Celsius (consensus)
Method: EM (single particle) / Resolution: 2.86 Å

73757

9z1z

EMDB-73757, PDB-9z1z:
Cryo-EM structure of human TRPM4 channel in complex with calcium and TPPO at 18 degrees Celsius (consensus)
Method: EM (single particle) / Resolution: 2.63 Å

73758

9z20

EMDB-73758, PDB-9z20:
Cryo-EM structure of human TRPM4 channel in complex with EGTA and TPPO at 37 degrees Celsius (consensus)
Method: EM (single particle) / Resolution: 2.51 Å

73759

9z21

EMDB-73759, PDB-9z21:
Cryo-EM structure of human TRPM4 channel in complex with calcium and NC1 at 37 degrees Celsius (consensus)
Method: EM (single particle) / Resolution: 2.83 Å

73760

9z22

EMDB-73760, PDB-9z22:
Cryo-EM structure of human TRPM4 channel in complex with EGTA and NC1 at 37 degrees Celsius (consensus)
Method: EM (single particle) / Resolution: 2.58 Å

73761

9z23

EMDB-73761, PDB-9z23:
Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA at 37 degrees Celsius (consensus)
Method: EM (single particle) / Resolution: 2.59 Å

73762

9z24

EMDB-73762, PDB-9z24:
Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved CBA density)
Method: EM (single particle) / Resolution: 3.1 Å

73763

9z25

EMDB-73763, PDB-9z25:
Cryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (consensus)
Method: EM (single particle) / Resolution: 2.64 Å

73764

9z26

EMDB-73764, PDB-9z26:
Cryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved NBA density)
Method: EM (single particle) / Resolution: 2.9 Å

73765

9z27

EMDB-73765, PDB-9z27:
Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA and DVT at 37 degrees Celsius (consensus)
Method: EM (single particle) / Resolution: 2.76 Å

Chemicals

ChemComp-CA:
Unknown entry

PDB-1cg5:
DEOXY FORM HEMOGLOBIN FROM DASYATIS AKAJEI

PDB-1cy8:
COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'-THYMIDINE MONOPHOSPHATE AND 3'-THYMIDINE MONOPHOSPHATE

PDB-1cz0:
INTRON ENCODED HOMING ENDONUCLEASE I-PPOI/DNA COMPLEX LACKING CATALYTIC METAL ION

PDB-1h0c:
The crystal structure of human alanine:glyoxylate aminotransferase

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / ion channel / TRP channel

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