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TitleStructure of the lysosomal KICSTOR-GATOR1 nutrient-sensing supercomplex
Journal, issue, pagesTo Be Published
Publish dateApr 9, 2025 (structure data deposition date)
AuthorsBayly-Jones C / Lupton CJ / Chang YG / Ellisdon AM
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.1 - 8.8 Å
Structure data

EMDB-70116: The KICSTOR-GATOR1 complex (consensus)
Method: EM (single particle) / Resolution: 8.8 Å

EMDB-70117: KICSTOR-GATOR1 complex (SZT2 [1-1330], NPRL2, NPRL3, DEPDC5) focused refinement.
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-70136: KICSTOR-GATOR1 dimer supercomplex (consensus)
Method: EM (single particle) / Resolution: 6.7 Å

72378

9xzy

EMDB-72378, PDB-9xzy:
DEPDC5 dimer (tandem DEPDC5) focused map
Method: EM (single particle) / Resolution: 3.8 Å

EMDB-72379: DEPDC5 NPRL2 NPRL3 SZT2 focused refinement
Method: EM (single particle) / Resolution: 3.9 Å

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / Lysosome / GATOR1 / KICSTOR / cell growth / amino acid sensing / mTOR / KPTN / ITFG2 / C12orf66 / SZT2 / NPRL2 / NPRL3 / DEPDC5

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