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Structure paper

TitleAI identifies Elite Antibodies that Tolerate Escape Mutations from a Population Antibody Class Exerting Continued Selection Over SARS-CoV-2
Journal, issue, pagesTo Be Published
Publish dateNov 2, 2025 (structure data deposition date)
AuthorsNiu C / Huang X / Yan Q / Liu B / Gao X / Song Y / Wang J / Wang L / Li Z / Zheng H ...Niu C / Huang X / Yan Q / Liu B / Gao X / Song Y / Wang J / Wang L / Li Z / Zheng H / He P / Yuan H / Zou B / Yang Y / Wu F / Yao Y / Chen X / Chen L / He J / Yao J / Zhao J / Xiong X
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.58 - 5.28 Å
Structure data

EMDB-66890, PDB-9xhy:
SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with C092 Fab and ACE2
Method: EM (single particle) / Resolution: 3.84 Å

EMDB-66891, PDB-9xhz:
SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with C092 Fab and ACE2 (2 RBD up)
Method: EM (single particle) / Resolution: 5.28 Å

EMDB-66892, PDB-9xi0:
SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with C092 Fab and ACE2 (3 RBD up)
Method: EM (single particle) / Resolution: 3.98 Å

EMDB-66893, PDB-9xi1:
SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with C092 Fab and ACE2
Method: EM (single particle) / Resolution: 2.58 Å

EMDB-66894, PDB-9xi2:
SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with C807 Fab and ACE2
Method: EM (single particle) / Resolution: 2.83 Å

EMDB-66895, PDB-9xi3:
SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with C807 Fab and ACE2 (3 RBD up)
Method: EM (single particle) / Resolution: 4.74 Å

EMDB-66896, PDB-9xi4:
SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with BD56-104 Fab and ACE2
Method: EM (single particle) / Resolution: 2.83 Å

EMDB-66897, PDB-9xi5:
SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with BD56-104 Fab and ACE2 (3 RBD up)
Method: EM (single particle) / Resolution: 3.06 Å

EMDB-66898, PDB-9xi6:
SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with BD56-597 Fab and ACE2
Method: EM (single particle) / Resolution: 2.6 Å

EMDB-66899, PDB-9xi7:
SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with BD56-597 Fab and ACE2 (3 RBD up)
Method: EM (single particle) / Resolution: 3.22 Å

EMDB-66900, PDB-9xi8:
Sarbecovirus GX2013 Spike S1 in complex with C092 Fab
Method: EM (single particle) / Resolution: 3.45 Å

EMDB-66901, PDB-9xi9:
SARS-CoV-2 Omicron LP.8.1 spike trimer (S-6P) in complex with 3 ZL58 Fabs and 3 ZL525 Fabs, focused refinement of RBD and Fab region
Method: EM (single particle) / Resolution: 2.93 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
  • btrs-betacov/gx2013 (virus)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM/HYDROLASE / Spike protein / Antibody Fab fragment / Complex / VIRAL PROTEIN-IMMUNE SYSTEM-HYDROLASE complex / VIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN-IMMUNE SYSTEM complex

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