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Structure paper

TitleMechanistic insights into the biosynthesis of Pseurotin A in Aspergillus fumigatus
Journal, issue, pagesTo Be Published
Publish dateOct 4, 2025 (structure data deposition date)
AuthorsSun L / Bai L
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.16 - 3.39 Å
Structure data

66474

9x29

EMDB-66474, PDB-9x29:
Cryo-EM structure of PsoA in cofactor bound state (PsoA-PKS-I)
Method: EM (single particle) / Resolution: 3.16 Å

66475

9x2a

EMDB-66475, PDB-9x2a:
Cryo-EM structure of PsoA in cofactor bound state (PsoA-PKS-II)
Method: EM (single particle) / Resolution: 3.36 Å

66476

9x2b

EMDB-66476, PDB-9x2b:
Cryo-EM structure of PsoA in apo state (PsoA-PKS-II)
Method: EM (single particle) / Resolution: 3.39 Å

Chemicals

ChemComp-MLC:
MALONYL-COENZYME A

ChemComp-COZ:
COENZYME A

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Source
  • Aspergillus fumigatus (mold)
  • aspergillus fumigatus af293 (mold)
KeywordsBIOSYNTHETIC PROTEIN / PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of pseurotin A

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