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Structure paper

TitleMechanistic Basis for 5-HT2AR Over 5-HT2BR Activation
Journal, issue, pagesTo Be Published
Publish dateSep 4, 2025 (structure data deposition date)
AuthorsTang L / Ji X / Cao D / Li H / Cheng J / Wang S
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.98 - 3.2 Å
Structure data

66114

9wnd

EMDB-66114, PDB-9wnd:
5HT2AR-miniGq heterotrimer in complex with a psychedelic psilocin
Method: EM (single particle) / Resolution: 3.2 Å

66116

9wnf

EMDB-66116, PDB-9wnf:
5HT2AR-miniGq heterotrimer in complex with a selective agonist IHCH-2330
Method: EM (single particle) / Resolution: 3.13 Å

66117

9wng

EMDB-66117, PDB-9wng:
5HT2BR-fab heterotrimer in complex with a novel antagonist IHCH-2330
Method: EM (single particle) / Resolution: 2.98 Å

Chemicals

ChemComp-91Q:
3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol / alkaloid*YM

PDB-1exy:
SOLUTION STRUCTURE OF HTLV-1 PEPTIDE BOUND TO ITS RNA APTAMER TARGET

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / GPCR / serotonin receptor / 5HT2AR / 5HT2BR

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