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Structure paper

TitleThe Mycobacterium abscessus cytochrome bcc:aa 3 oxidase structure paves the way for an agent targeting subunit QcrB.
Journal, issue, pagesNat Commun, Vol. 17, Year 2026
Publish dateAug 18, 2025 (structure data deposition date)
AuthorsVikneswaran Mathiyazakan / Emilia Xin Yi Tan / Garrett Moraski / Sandip Basak / Wuan-Geok Saw / Kevin Pethe / Gerhard Grüber /
PubMed AbstractThe cytochrome bcc:aa oxidase is the target of telacebec, a clinically advanced drug developed for Mycobacterium tuberculosis. However, telacebec is inactive against Mycobacterium abscessus, an ...The cytochrome bcc:aa oxidase is the target of telacebec, a clinically advanced drug developed for Mycobacterium tuberculosis. However, telacebec is inactive against Mycobacterium abscessus, an opportunistic pathogen increasingly linked to chronic pulmonary infections and notoriously known for intrinsic resistance to numerous antibiotics. Here, we report the 2.6 Å cryo-electron microscopy structure of the M. abscessus bcc:aa cytochrome oxidase supercomplex, revealing key pathways and the evolution of the mycobacterial QcrB menaquinol-binding cavity. Structure-guided mutagenesis identified polymorphisms that modulate telacebec binding and potency in both M. abscessus and Mycobacterium smegmatis. Leveraging these insights, we designed ND-011458, a QcrB inhibitor with potent activity against M. abscessus and being bactericidal in combination with Clofazimine. The 2.26 Å inhibitor-bound structure elucidates its binding mode and provides a framework for the design of next-generation inhibitors for M. abscessus pulmonary diseases.
External linksNat Commun / PubMed:41932870 / PubMed Central
MethodsEM (single particle)
Resolution2.26 - 2.66 Å
Structure data

PDB-9wcx:
Cryo-EM structure of the Mycobacterium abscessus cytochrome bcc:aa3 supercomplex
Method: ELECTRON MICROSCOPY / Resolution: 2.66 Å

PDB-9wcy:
Cryo-EM structure of the Mycobacterium abscessus cytochrome bcc:aa3 supercomplex in the presence of ND-011458
Method: ELECTRON MICROSCOPY / Resolution: 2.26 Å

Chemicals

ChemComp-9XX:
(2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate

ChemComp-CDL:
CARDIOLIPIN / phospholipid*YM

ChemComp-9Y0:
(2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate

ChemComp-HEA:
HEME-A

ChemComp-CU:
COPPER (II) ION

ChemComp-PLM:
PALMITIC ACID

ChemComp-OXY:
OXYGEN MOLECULE

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

ChemComp-9YF:
(2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate

ChemComp-MQ9:
MENAQUINONE-9

ChemComp-HEC:
HEME C

ChemComp-HOH:
WATER

PDB-1mbf:
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1

Source
  • mycobacteroides abscessus (bacteria)
KeywordsOXIDOREDUCTASE / Apo structure of Supercomplex / Inhibitor bound Supercomplex

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