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TitleAbeta fibrils from brains of 5xFAD and AppNL-FPsen1P117L mice adopt human Type II fibril fold as revealed by cryo-EM
Journal, issue, pagesTo Be Published
Publish dateAug 12, 2025 (structure data deposition date)
AuthorsCao Q / Zhang D / Song M / Zheng H / Han J / Xu K
External linksSearch PubMed
MethodsEM (helical sym.)
Resolution3.22 - 3.5 Å
Structure data

65825

9wao

EMDB-65825, PDB-9wao:
Structure of type II Abeta fibrils from 5xFAD mice
Method: EM (helical sym.) / Resolution: 3.5 Å

65826

9wap

EMDB-65826, PDB-9wap:
Structure of Type II Abeta fibrils from AppNL-FPsen1P117L mice
Method: EM (helical sym.) / Resolution: 3.22 Å

67622

21fb

EMDB-67622, PDB-21fb:
Structure of minor species of Abeta fibrils from AppNL-FPsen1P117L mice
Method: EM (helical sym.) / Resolution: 3.4 Å

Source
  • Mus musculus (house mouse)
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / Abeta / amyloid / cryo-EM

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