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TitleStructural basis for the inhibition of cystathionine-b-synthase by isoflurane and its role in anaesthesia-induced social dysfunction in mice
Journal, issue, pagesBritish Journal of Anaesthesia, Vol. 3, Page 746-758, Year 2025
Publish dateJul 10, 2025 (structure data deposition date)
AuthorsXu, K.
External linksBritish Journal of Anaesthesia / PubMed:39603853
MethodsX-ray diffraction
Resolution3.03 Å
Structure data

PDB-9vtf:
Structural basis for the inhibition of cystathionine-b-synthase by isoflurane
Method: X-RAY DIFFRACTION / Resolution: 3.03 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-4LE:
(2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

Source
  • homo sapiens (human)
KeywordsBIOSYNTHETIC PROTEIN / hydrogen sulfide (H2S) biosynthesis / metabolism of homocysteine

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